Cytokines and migraine: increase of IL-5 and IL-4 plasma levels

Headache
I MunnoO Albano

Abstract

Thirty-two patients suffering from migraine without aura were assessed during in interictal period to evaluate the contribution of cytokines to the pathophysiology of migraine. To this end, plasma levels of IFN-gamma, IL-4, IL-5, and IL-10 were measured by enzyme-linked immunosorbent assay (ELISA) techniques. Plasma levels of both IFN-gamma and IL-10 were not increased in the patients and did not differ significantly from healthy controls. Of interest, we observed a strong increase of IL-5 levels in 84.3% as well as increased IL-4 levels in 37.5% of patients with migraine without aura. These results suggests a preferential enhancement of some Th2-type cytokines, and may support the growing arguments of an immunoallergic mechanism in the pathophysiology of migraine.

Citations

Mar 29, 2002·Annals of Neurology·Rajani ChoudhuriNancy E J Berman
Jun 7, 2011·Journal of Neural Transmission·Arpád PárdutzLászló Vécsei
Aug 23, 2002·Pharmacology & Therapeutics·Paul L Durham, Andrew F Russo
Jul 9, 2002·Cephalalgia : an International Journal of Headache·R LeiraJ Castillo
Apr 11, 2012·American Journal of Therapeutics·Aron D MosnaimMarion E Wolf
Jan 29, 2013·American Journal of Therapeutics·Aron D MosnaimMarion E Wolf
Feb 2, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ibrahim Arda YilmazOsman Ozgür Yalin
Sep 15, 2009·Pediatric Neurology·Tugba HirfanogluAli Cansu
Jun 13, 2009·Pediatric Neurology·Leszek BoćkowskiBeata Zelazowska-Rutkowska
Dec 30, 2015·Journal of Neuroimmunology·Murugesan Arumugam, Varadarajan Parthasarathy
Feb 19, 2011·The Journal of Headache and Pain·Anita TrauningerZoltán Pfund
Sep 24, 2005·Headache·Rogelio LeiraUNKNOWN Stroke Project, Cerebrovascular Diseases Group of the Spanish Neurological Society
Mar 16, 2007·Headache·Federico A SilvaPatricio López-Jaramillo
Dec 6, 2005·Journal of Neuroimmunology·Işil FidanF Nur Aksakal
Feb 6, 2015·Current Neurology and Neuroscience Reports·Andrea M Harriott, Kevin M Barrett
May 29, 2010·Pharmacological Reports : PR·Leszek BoćkowskiKrzysztof Sendrowski
May 19, 2018·Frontiers in Immunology·Jéssica Barletto de Sousa BarrosIrmtraut Araci Hoffmann Pfrimer
Sep 7, 2020·CNS Neuroscience & Therapeutics·Sedigheh FarahaniReza Mirfakhraie
Jun 20, 2019·Frontiers in Immunology·Marisa FlookJose Antonio Lopez-Escamez
Feb 13, 2020·Frontiers in Immunology·Gilson Gonçalves Dos SantosMaripat Corr
Jul 21, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marcelo FilipchukMarco Lisicki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.