Cytokines and radiation-induced pulmonary injuries

Journal of Radiation Research
Anna LierovaZuzana Sinkorova

Abstract

Radiation therapy is one of the most common treatment strategies for thorax malignancies. One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is the major dose-limiting organ for radiotherapy. That is because ionizing radiation produces reactive oxygen species that induce lesions, and not only is tumor tissue damaged, but overwhelming inflammatory lung damage can occur in the alveolar epithelium and capillary endothelium. This damage may result in radiation-induced pneumonitis and/or fibrosis. While describing the lung response to irradiation generally, the main focus of this review is on cytokines and their roles and functions within the individual stages. We discuss the relationship between radiation and cytokines and their direct and indirect effects on the formation and development of radiation injuries. Although this topic has been intensively studied and discussed for years, we still do not completely understand the roles of cytokines. Experimental data on cytokine involvement are fragmented across a large number of experimental studies; hence, the need for this review of the current knowledge. Cytokines are considered not only as molecular factors involved in the signaling netwo...Continue Reading

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Citations

Oct 28, 2019·Journal of Cellular and Molecular Medicine·Lei ZhengJia-Yi Chen
Sep 10, 2020·Frontiers in Pharmacology·Anna LierovaZuzana Sinkorova
Oct 19, 2019·Cancers·Simone de LeveVerena Jendrossek
Dec 22, 2020·Frontiers in Pharmacology·Vidya P KumarSanchita P Ghosh
Oct 17, 2020·Radiation Research·Carmen I RiosAndrea L DiCarlo
Jul 3, 2021·Nature Reviews. Immunology·Urszula M CytlakTimothy M Illidge
Dec 21, 2021·Frontiers in Immunology·Zengfu ZhangDawei Chen

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Methods Mentioned

BETA
transgenic
bronchoalveolar lavage
ELISA
PCR
RNA
RNA assay
biopsies
transfection

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