Cytokines as adjuvants for vaccines: antigen-specific responses differ from polyclonal responses.

Infection and Immunity
C E Taylor

Abstract

The use of cytokines in the administration of vaccines has a unique value in obtaining the appropriate immune response and in ensuring a protective outcome. Earlier studies indicating that cytokines can influence the generation of a particular antibody isotype may represent an oversimplification of a more complex problem. Several studies discussed in this review show that the effect of a given cytokine on the immune response depends on whether one examines the antigen-specific response or the polyclonal response (i.e., total serum immunoglobulins). Further, a balanced regulation of immune responsiveness is important in maintaining homeostasis of the immune system. Consequently, for any vaccine that uses cytokines to boost the response, due consideration must be given to these important variables.

References

Feb 1, 1992·Lupus·N A Granholm, T Cavallo
May 7, 1992·Nature·W E Paul
Mar 1, 1992·European Journal of Immunology·A O'GarraM Howard
Jan 11, 1990·Annual Review of Immunology·F D FinkelmanW E Paul
Jan 1, 1991·Advances in Experimental Medicine and Biology·J R McGheeH Kiyono
Nov 1, 1991·Science·R KühnW Müller
May 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M PasatiempoA C Ross
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D A LebmanF D Lee
Jun 1, 1986·Clinical Immunology and Immunopathology·I R KatzM K Hoffmann
Jan 1, 1987·The Journal of Experimental Medicine·J P CoutelierJ Van Snick
Apr 1, 1994·The Journal of Experimental Medicine·Y WakatsukiW Strober
May 1, 1994·The Journal of Experimental Medicine·T KurosakiH Yamamura
Jul 1, 1994·Scandinavian Journal of Immunology·R van OmmenH F Savelkoul
May 1, 1993·Trends in Pharmacological Sciences·F Powrie, R L Coffman
May 1, 1994·Journal of Neurochemistry·M KörnerP Debré
May 1, 1994·Journal of Leukocyte Biology·R S Wallis, J J Ellner
Oct 1, 1993·Immunology and Cell Biology·A D NashA E Andrews
Jan 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·C W Czarniecki, G Sonnenfeld
Apr 1, 1993·European Journal of Immunology·K E CostelloeR E Callard

❮ Previous
Next ❯

Citations

Apr 27, 2001·Immunopharmacology and Immunotoxicology·T Krakauer, C Russo
Jan 1, 2014·Vaccines·Rachel StephensonIstvan Toth
Apr 9, 2001·Clinical Microbiology Reviews·P L OgraR C Welliver
Aug 1, 1996·Journal of Virology·T M MoranJ L Schulman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Related Papers

International Journal of Immunopathology and Pharmacology
P MansuetoE Cillari
Annals of the New York Academy of Sciences
Monika ØstensenPeter M Villiger
Springer Seminars in Immunopathology
C Infante-Duarte, T Kamradt
Veterinary Immunology and Immunopathology
W C BrownD M Estes
© 2021 Meta ULC. All rights reserved