PMID: 9192505Jul 1, 1997Paper

Cytokines expressed in multinucleated cells: Paget's disease and giant cell tumors versus normal bone

Calcified Tissue International
B G Mills, A Frausto

Abstract

Human osteoclasts are well characterized multinucleated cells whose function is the directed resorption of normal bone (NB). Osteoclastic bone destruction accompanies lytic solid tumors and myeloma as well as Paget's disease (PD) of bone and giant cell tumors of bone (GCTB). The mechanism of this stimulation of osteoclastic bone resorption is unknown. This study was designed to detect cytokines present in the multinucleated cells of PD and GCTB in order to determine whether cytokine abnormalities exist to account for bone lysis. Nine cytokines, representing the functions of bone resorption, angiogenesis, tumor necrosis, bone cell proliferation, and osteoblast-osteoclast coupling, were examined by immunohistochemistry using tissue samples from 15 NB, 17 PD, and 19 GCTB patients. Standard nonparametric statistical analysis showed a significant increase (P < 0.01 to 0.05) in immunostaining between osteoclasts of PD and NB for interleukin-6 (Il-6), tumor necrosis factor beta (TNFbeta), epidermal growth factor (EGF), platelet derived growth factor (PDGF), and basic fibroblast growth factor (bFGF). There was a statistically significant decrease in immunostaining of giant cells of GCTB as compared with NB for transforming growth facto...Continue Reading

Citations

Oct 6, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P G Robey, P Bianco
Jan 8, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·H S Schwartz, M G Butler
Apr 8, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R K RudeJ Kilburn
Sep 10, 2005·Calcified Tissue International·M Laroche, A Delmotte
Jun 27, 2009·Molecular Endocrinology·Kumaran SundaramSakamuri V Reddy
Oct 29, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B G MillsE Brien
Oct 12, 2000·Cytokine·D Heymann, A V Rousselle
Sep 25, 2007·Journal of Cellular Biochemistry·Kumaran SundaramSakamuri V Reddy
Nov 30, 2005·Immunological Reviews·Lori A Ehrlich, G David Roodman
Oct 6, 2011·Acta Biomaterialia·Ziyang ZhangArndt F Schilling
Jul 28, 2004·The American Journal of Pathology·Jan H N LindemanPancras C W Hogendoorn
Oct 16, 1999·Journal of Dental Research·N Tani-IshiiT Umemoto
Mar 3, 2020·Frontiers in Physiology·Eugenio Hardy, Carlos Fernandez-Patron

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