Cytokines for monitoring anti-tuberculous therapy: A systematic review

Tuberculosis
Vanessa CliffordNigel Curtis

Abstract

The ability to monitor response to therapy for tuberculosis (TB) and confirm adequate treatment would be a major advance. The low reversion rate of interferon-gamma based assays means that they are unlikely to be useful for monitoring therapy. Several exploratory studies have evaluated the diagnostic potential of cytokine biomarkers other than interferon-gamma for monitoring anti-tuberculous therapy. A systematic review of these studies was performed to identify the most promising candidate biomarkers. TNF-α, IL-2, IL-6, IL-10 and IL-12 were the most extensively investigated cytokines. There was significant heterogeneity between studies in relation to study design and laboratory methodology, complicating direct comparisons. There was marked variation between studies in the observed changes during treatment for many of the biomarkers. Further longitudinal studies in sufficiently large patient cohorts with rigorous methodology are needed to determine the true potential of individual cytokine biomarkers, or combinations, for monitoring TB treatment.

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Citations

Jun 1, 2016·International Journal of Mycobacteriology·Najeeha Talat IqbalGhaffar Dawood
Mar 10, 2016·BMC Infectious Diseases·Joseph MendyJayne S Sutherland
Aug 15, 2015·The Journal of Infection·Vanessa CliffordNigel Curtis
Apr 1, 2016·Expert Review of Respiratory Medicine·Neesha RockwoodRobert J Wilkinson
Jun 2, 2015·American Journal of Respiratory and Critical Care Medicine·Marc TebrueggeNigel Curtis
Nov 28, 2017·Cellular & Molecular Immunology·Hongbo Shen, Zheng W Chen
Jul 10, 2019·Open Forum Infectious Diseases·Nathella Pavan KumarSubash Babu
Nov 27, 2018·Open Forum Infectious Diseases·Douglas WilsonGary Maartens
May 15, 2018·The Journal of International Medical Research·Xuejiao LuoHaiyan Cui
May 8, 2020·Journal of Immunology Research·Mariana HerreraZulma Vanessa Rueda
Jul 14, 2017·Pneumonia·Claudia L Roya-Pabon, Carlos M Perez-Velez
Jun 25, 2015·The Pediatric Infectious Disease Journal·Marc TebrueggeDelane Shingadia

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