Oct 1, 1989

Cytokines in cancer therapy

Urology
D R Parkinson

Abstract

Cytokines, small biological response modifying proteins produced by hematopoietic and other cells, may one day play a significant role in the treatment of human cancer. This article presents an overview of the cytokines, including descriptions of their origins, mechanisms of action, and antitumor activities. Several classes of cytokines are discussed, including the interferons, the interleukins, and tumor necrosis factor. Several of these agents, either alone or in combination, are currently involved in clinical trials for the treatment of specific cancers. Th interaction of cytokines and monoclonal antibodies is also discussed.

Mentioned in this Paper

Interleukins
Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Tumor Necrosis Factor-alpha
Neoplasms
Recombinant Interleukins
Interferons
Recombinant Interferon
MUROMONAB-CD3, Parenteral,5 MG Administered
Cytokine

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