Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis

Schizophrenia Research
Juan A GallegoAnil K Malhotra

Abstract

Few studies have been conducted examining cytokines in cerebrospinal fluid of patients compared to healthy volunteers. The goals of this study were: 1) to report original data detailing cytokine levels in the cerebrospinal fluid (CSF) of 10 patients with a schizophrenia spectrum disorder (SSD) diagnosis and 10 healthy controls and 2) to conduct a meta-analysis of the available data on cytokine levels in the CSF of patients with SSD compared to healthy controls, including our new data. Cytokine concentrations were measured using the Q-plex Human Cytokine Screen array in CSF of 10 patients with SSD and 10 healthy volunteers. For the meta-analysis, an electronic PubMed and Google Scholar search without restrictions was conducted for articles that reported on cytokine levels in CSF in patients with an SSD compared to healthy controls. Our original data revealed statistically significant increases in levels of interleukin-8 (IL-8) and interleukin-1 beta (IL-1β) in the CSF of patients with an SSD compared to healthy volunteers. Our meta-analysis showed statistically significant increases in interleukin-6 (IL-6) and IL-8 in patients compared to healthy volunteers. Effect sizes between treated and untreated patients for IL-6 were of si...Continue Reading

Citations

Jun 5, 2019·Current Neuropharmacology·Pablo L CardozoFabíola M Ribeiro
Mar 18, 2020·Acta Neuropsychiatrica·Mario Gennaro MazzaMassimo Clerici
Sep 24, 2020·Molecular Genetics & Genomic Medicine·Mansour ZamanpoorMir Davood Omrani
Mar 11, 2020·Frontiers in Psychiatry·David R Goldsmith, Mark Hyman Rapaport
Feb 1, 2020·Indian Journal of Psychiatry·Venkataram ShivakumarGanesan Venkatasubramanian
Jul 29, 2019·Metabolic Brain Disease·Amir Abdoli, Hoda Mirzaian Ardakani
Jan 6, 2021·The American Journal of Psychiatry·Nina V KraguljacCharles B Nemeroff
Apr 28, 2020·Schizophrenia Research·John R KellyTimothy G Dinan
Jan 1, 2021·Developmental Neurobiology·Martyna PekalaKatarzyna Kalita
Mar 30, 2020·Journal of Psychosomatic Research·Zhili ZouTao Li
Mar 6, 2021·Schizophrenia Research·Daniela EnacheValeria Mondelli
Mar 14, 2021·Neuroscience and Biobehavioral Reviews·Fabiana Corsi-Zuelli, Bill Deakin
Mar 20, 2021·Psychoneuroendocrinology·Błażej MisiakBrian J Miller
Nov 14, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Shih-Jen Tsai
Apr 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yazhen WangHuile Gao
Apr 21, 2021·Brain : a Journal of Neurology·Alexis M CrockettJorge I Alvarez
May 23, 2021·Pharmacological Reports : PR·Katarzyna ChameraAgnieszka Basta-Kaim
Oct 16, 2021·Translational Psychiatry·Caitlin E MurphyCynthia Shannon Weickert

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.