PMID: 7542377Aug 1, 1995Paper

Cytokines in fetal blood and amniotic fluid in Rh-immunized pregnancies

Obstetrics and Gynecology
M WestgrenM Stangenberg

Abstract

To determine fetal serum and amniotic fluid (AF) levels of interleukin (IL)-3, IL-6, granulocyte-macrophage colony-stimulating factor, stem cell factor, and erythropoietin, and to explore the relationship between cytokines and hemoglobin concentration, white blood cell count (WBC), and platelet count in fetuses affected by Rh immunization. Thirty-four consecutive Rh-immunized patients in gestational weeks 19-33 were included. All patients were investigated by funipuncture and 13 by amniocentesis. The levels of IL-3, IL-6, granulocyte-macrophage colony-stimulating factor, stem cell factor, and erythropoietin were estimated using commercially available immunoassays. There was a significant correlation between erythropoietin concentrations in fetal serum and AF (r = 0.54, P < .05), whereas none of the other cytokines showed a positive correlation between these two compartments. Fetal serum contained higher concentrations of IL-3, granulocyte-macrophage colony-stimulating factor, stem cell factor, and erythropoietin compared with AF. In contrast, the IL-6 level was significantly higher in AF compared with fetal serum (P = .002). Erythropoietin and IL-3 levels were both negatively correlated with fetal hemoglobin concentrations (r =...Continue Reading

References

Mar 1, 1990·American Journal of Obstetrics and Gynecology·M C Van den Hof, K H Nicolaides
May 1, 1990·The Journal of Clinical Investigation·R RomeroP B Sehgal
Jan 1, 1989·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·R DasariM Feld

❮ Previous
Next ❯

Citations

Aug 30, 2003·Cytokine·Katarzyna Bogunia-KubikShara B A Cohen
Mar 20, 1998·Pediatric Research·T StallmachM Gassmann
Nov 1, 1995·British Journal of Obstetrics and Gynaecology·L NordströmM Westgren
Jan 25, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Elisabeth R MathiesenPeter Damm
Jul 4, 2006·American Journal of Obstetrics and Gynecology·Robert A BraceJohn A Widness
Apr 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·William G Johnson
May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joachim Fandrey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Journal of Perinatology : Official Journal of the California Perinatal Association
Nicole M SchmidtJohn A Widness
Pediatrics International : Official Journal of the Japan Pediatric Society
Fujio KakuyaKiminori Sasaki
American Journal of Reproductive Immunology : AJRI
R RaghupathyF Azizieh
© 2021 Meta ULC. All rights reserved