PMID: 15222255Jun 30, 2004Paper

Cytokines in heart failure

Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
António Ferreira

Abstract

Cytokines are produced in the heart and at the periphery in response to stimuli such as ischemia, left ventricular (LV) overload and endotoxemia. Acting on specific receptors located at the cell membrane, they promote cardiac dysfunction by producing LV enlargement, reducing LV systolic function and inducing apoptosis. These effects stem directly from the cytokines' actions or are dependent on the increased synthesis of nitric oxide and sphingosine. The cytokines are able to increase their own synthesis, by a positive feedback mechanism, thus perpetuating their actions and leading to the progression of heart failure (HF). Despite the available evidence linking cytokines to the pathogenesis of HF and its progression, anti-cytokine therapy has not yet been shown to be effective in patients with HF. In this paper, the molecular mechanisms involved in cytokine synthesis and actions are reviewed.

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Clinical Reviews in Allergy & Immunology
Daniela MariMassimo Cugno
Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
Namik OzmenEjder Kardeşoğlu
American Journal of Therapeutics
Ehab S El Desoky
© 2022 Meta ULC. All rights reserved