Cytokines in primary biliary cirrhosis

Seminars in Liver Disease
P A BergM Röcken

Abstract

Immunoreactivity to intra- and extracellular antigens is regulated mainly by two different types of T-helper cells, namely TH1 (producing mainly IFN-gamma and Il-2) and TH2 (producing IL-4, -5, -10). Both types cross-regulate each other. TH1 mechanisms seem to be involved principally in organ-specific autoaggressive disorders, while TH2 response is an expression of allergic conditions characterized by eosinophilic reactions and increased IgE levels. There are only a few reports dealing with cytokine profiles in patients with primary biliary cirrhosis (PBC). From studies analyzing the cytokine gene expression and cytokines in supernatants of nonstimulated and antigen-specific lymphocytes derived from the affected liver or peripheral blood of PBC patients, there is evidence that, in the course of the disease, predominantly TH1 cells are activated. However, in view of the eosinophilic reaction observed especially in patients with early PBC, it may well be that a switch from TH2 to TH1 occurs. Concerning the regulatory function of TH1/TH2 cells, a more refined evaluation of these T-cell subsets could help to provide a new insight into the natural course of PBC.

Citations

Dec 22, 1999·Journal of Hepatology·S M CruickshankL K Trejdosiewicz
Apr 13, 1999·Gastroenterology Clinics of North America·A StiehlP Sauer
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G M Stein, P A Berg
Jul 10, 2003·Autoimmunity Reviews·Hiromi IshibashiM Eric Gershwin
Aug 8, 2002·Clinical and Experimental Immunology·J M PalmerD E J Jones
May 27, 2009·Seminars in Immunopathology·Hiromi IshibashiShinji Shimoda
Nov 25, 2000·Clinical and Experimental Immunology·T YamanoT Tsuji
Aug 29, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E J JonesJohn A Kirby
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Neuberger
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K TjandraM G Swain
Feb 23, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Tom H KarlsenKirsten M Boberg
Feb 5, 2008·Clinics in Liver Disease·Kerri Novak, Mark G Swain
Nov 25, 2004·Clinics in Liver Disease·V J Desmet
Aug 23, 2011·Clinical Science·Marcelo G RomaEnrique J Sánchez Pozzi
Feb 16, 2015·Clinical Reviews in Allergy & Immunology·Ying SunM Eric Gershwin
Sep 8, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·Y NakanumaK Harada
Apr 14, 2000·Journal of Gastroenterology and Hepatology·M StrazzaboscoL Okolicsanyi
Oct 14, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Osamu KidoTooru Shimosegawa
Mar 19, 2004·European Journal of Gastroenterology & Hepatology·Kalliopi ZachouGeorgios N Dalekos
Jul 6, 2006·Medical Molecular Morphology·Kenichi Harada, Yasuni Nakanuma
Oct 13, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenichi Harada, Yasuni Nakanuma
Oct 13, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Sabine OerteltM Eric Gershwin
Apr 28, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yasushi TakiiHiromi Ishibashi
Oct 19, 2011·International Journal of Hepatology·Masashi NinomiyaTooru Shimosegawa
Jun 30, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lindsey KennedyGianfranco Alpini
Mar 11, 2005·Journal of Clinical Gastroenterology·Michael TraunerGernot Zollner
Mar 20, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·J M McGillA P Stansfield

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