PMID: 8585935Nov 1, 1995Paper

Cytokines in proliferative diabetic retinopathy and proliferative vitreoretinopathy

Current Eye Research
S G ElnerR M Strieter

Abstract

We determined whether interleukin-8, monocyte chemotactic protein-1, and macrophage-colony stimulating factor are present in the vitreous of patients with proliferative diabetic retinopathy (PDR) or proliferative vitreoretinopathy (PVR). The levels of these cytokines were measured by specific enzyme-linked immunoassays in vitreous from 30 patients with PDR, 13 patients with PVR, and 26 control individuals, including 10 cadaver eyes and 16 patients with idiopathic macular holes, idiopathic macular puckers, vitreous hemorrhages, or uncomplicated retinal detachments. Detectable levels of interleukin-8 were found in 90% of vitreous samples of patients with PDR, 85% with PVR, and 58% of control samples. IL-8 was significantly increased in PDR (mean +/- SEM; 25.0 +/- 5.3 ng/ml; p = 0.01), but not in PVR (11.9 +/- 3.9 ng/ml; p = 0.50) compared to control human vitreous (8.5 +/- 2.5 2.5 ng/ml). MCP-1 was detected in 90% of vitreous samples of patients with PDR, 92% with PVR, and 81% of control samples. MCP-1 was significantly increased in PDR (6.2 +/- 0.9 ng/ml, p = 0.001) and PVR (7.7 +/- 2.5 ng/ml, p = 0.001) over the levels in control vitreous (1.2 +/- 0.2 ng/ml). M-CSF was detected in 94% of vitreous samples of patients with PDR, 8...Continue Reading

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Citations

Jan 1, 1997·Eye·A Kijlstra
May 29, 1998·The British Journal of Ophthalmology·M A BurnstineV M Elner
Mar 27, 2001·The British Journal of Ophthalmology·I A El-GhrablyP J Tighe
Jun 26, 2001·The British Journal of Ophthalmology·A YoshidaV M Elner
Nov 12, 2003·The British Journal of Ophthalmology·J TrogerW Göttinger
Oct 11, 2012·Mediators of Inflammation·Stavros N MoysidisDemetrios G Vavvas
May 3, 2008·Investigative Ophthalmology & Visual Science·Guangpu ShiSheldon S Miller
Jul 13, 2013·Investigative Ophthalmology & Visual Science·Monique S RoyRobert Donnelly
Dec 10, 2009·PloS One·Takeru YoshimuraTatsuro Ishibashi
Aug 8, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sumeyya AkyolOmer Akyol
Oct 4, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Jing-Ru XiaoChi-Ho To
Apr 18, 2009·Seminars in Ophthalmology·Yannek I Leiderman, Joan W Miller
Mar 23, 2002·Current Eye Research·W H GarnerG Graff
May 15, 2010·Current Eye Research·Rifat RasierHalil Bahcecioglu
Nov 10, 2009·Current Eye Research·Nobuyuki EbiharaAkira Murakami
Mar 8, 2014·Journal of Cellular Physiology·Gian Marco TosiPaolo Toti
May 7, 2013·Survey of Ophthalmology·Justus G GarwegMarkus Halberstadt
May 5, 2011·Microvascular Research·Natalia MarekPiotr Trzonkowski
Jun 12, 2004·The Journal of Investigative Dermatology·Ghada NaguibDana T Graves
May 25, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·C HernándezR Simó
Dec 1, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A TashimoJ Nishihira
Dec 23, 2006·Journal of Cellular Physiology·Jesus P CamiñaFelipe F Casanueva
May 30, 2006·Diabetes Research and Clinical Practice·Chikako HaradaTakayuki Harada
May 6, 2006·Experimental Eye Research·Susan G ElnerVictor M Elner
Feb 11, 2015·Cell Biochemistry and Biophysics·Peipei Zhang, Zhanyu Zhou

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