PMID: 7536795May 1, 1995Paper

Cytokines increase human hemopoietic cell adhesiveness by activation of very late antigen (VLA)-4 and VLA-5 integrins

The Journal of Experimental Medicine
J P LévesqueP J Simmons

Abstract

Cytokines are known to be important regulators of normal hemopoiesis, acting in concert with components of the bone marrow microenvironment. Interactions with this microenvironment are known to regulate the proliferation, differentiation, and homing of hemopoietic progenitor (CD34+) cells. Adhesive interactions with the extracellular matrix retain CD34+ cells in close proximity to cytokines, but may also provide important costimulatory signals. Thus, the functional states of adhesion receptors are critical properties of CD34+ cells, but the physiological mechanisms responsible for regulating functional properties of cell adhesion receptors on primitive hemopoietic cells are still unknown. We confirm that the integrins very late antigen (VLA)-4 and VLA-5 are expressed on the CD34+ cell lines MO7e, TF1, and on normal bone marrow CD34+ progenitor cells, but in a low affinity state, conferring on them a weak adhesive phenotype on fibronectin (Fn). Herein, we show that the cytokines interleukin (IL)-3, granulocyte-macrophage CSF (GM-CSF), and KIT ligand (KL) are physiological activators of VLA-4 and VLA-5 expressed by MO7e, TF1, and normal bone marrow CD34+ progenitor cells. Cytokine-stimulated adhesion on Fn is dose dependent and t...Continue Reading

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Citations

Sep 30, 2000·Stem Cells·M Körbling
Feb 6, 2003·International Journal of Hematology·Tsutomu WatanabeJames E Talmadge
Feb 15, 2001·Pathology Oncology Research : POR·M Rosendaal, T Krenács T
Aug 26, 2009·Bulletin of Experimental Biology and Medicine·A P ZhambalovaL B Buravkova
Jul 16, 2008·Journal of Materials Science. Materials in Medicine·Shikhar VohraSusan L Bellis
Jan 22, 2004·Archives of Medical Research·Héctor MayaniPatricia Flores-Guzmán
Sep 10, 2003·Experimental Hematology·Bianling LiuJohannes C M van der Loo
Apr 21, 1999·Experimental Hematology·J P Lévesque, P J Simmons
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·L K Ashman
Dec 22, 1999·British Journal of Haematology·F Sanz-RodríguezJ Teixidó
Feb 13, 2001·British Journal of Haematology·F de BoerG J Schuurhuis
Jun 1, 1999·Journal of Hematotherapy·E F SrourC M Traycoff

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