PMID: 9178108May 1, 1997Paper

Cytokines modulate routes of collagen breakdown. Review with special emphasis on mechanisms of collagen degradation in the periodontium and the burst hypothesis of periodontal disease progression

Journal of Clinical Periodontology
E van der ZeeW Beertsen

Abstract

In this paper, we review recent work on collagen degradation, 2 main routes of breakdown are described and their relevance during healthy and inflammatory conditions of the periodontium is discussed. Special attention is paid to the possible role of cytokines, in particular interleukin 1 (IL-1) and transforming growth factor beta (TGF-beta), on the modulation of collagen phagocytosis and metalloproteinase production. IL-1 has been shown to have a dual function in collagen digestion. It inhibits the intracellular phagocytic pathway, but at the same time, it strongly promotes extracellular digestion by inducing the release of collagenolytic enzymes like collagenase. TGF-beta has an opposite effect on both pathways and antagonizes IL-1. Collagenase is released in an inactive form, and a considerable fraction of the proenzyme may become incorporated in the extracellular matrix. This reservoir of latent enzyme can be activated (for instance by plasmin), leading to a sudden and extensive breakdown of the collagenous fibre meshwork. It is suggested that this phenomenon may also take place during progressive periodontitis and could explain an episodic nature of collagenolysis, clinically resulting in bursts of attachment loss (burst hy...Continue Reading

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Citations

Feb 1, 2000·Journal of Cellular Physiology·M KataokaT Nagata
Feb 13, 2001·Journal of Clinical Periodontology·M DahanH Tenenbaum
Aug 9, 2001·Journal of Clinical Periodontology·M BickelR Attström
Apr 23, 2002·Journal of Clinical Periodontology·Lydie Izakovicova HollaVladimir Znojil
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May 14, 2005·BMC Medical Imaging·Allan HynesKan-Zhi Liu
Jan 8, 2008·Arthritis Research & Therapy·Raimund W KinneGerd-R Burmester
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Oct 6, 2005·Biological & Pharmaceutical Bulletin·Masatoshi KataokaToshihiko Nagata
Oct 2, 2001·Journal of Periodontology·O Oettinger-BarakM Peled
Apr 2, 2003·Journal of Periodontology·Anne-Laure EjeilBruno Gogly
Apr 25, 2003·Journal of Periodontology·D T Graves, D Cochran
Jul 16, 2008·Journal of Periodontal Research·L D R GonçalvesE J Feres-Filho
Apr 27, 2004·Periodontology 2000·Nicolas Delaleu, Matthias Bickel
Jul 17, 2001·Periodontology 2000·D F KinaneJ Ebersole
Sep 5, 2017·Acta Odontologica Scandinavica·Hager R Zein ElabdeenAnne Isine Bolstad
Oct 31, 2019·International Journal of Immunopathology and Pharmacology·Scapoli LucaSeverino Marco
Aug 28, 2003·Journal of Periodontal Research·Masatoshi KataokaToshihiko Nagata

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