PMID: 9557956Apr 29, 1998Paper

Cytokines serum levels as the markers of thyroid activation in Graves' disease

Immunology Letters
J KomorowskiH Stepień

Abstract

In order to examine which cytokine could be used as a marker of the biological effect of thyroid hormones or anti-thyroid antibodies in Graves' disease (GD) patients, we simultaneously evaluated the concentrations of TSH, free thyroid hormones (fT3 and fT4), anti-thyroid antibodies (anti-TPO and anti-TG) and a group of cytokines: interleukin-2 (IL-2), tumour necrosis factor alpha (TNFalpha), interleukin-6 (IL-6) and their soluble receptors (sIL-2R, sTNFalphaR, sIL-6R) as well as interleukin-10 (IL-10) in eight GD females and nine normal controls. We found that serum sIL-2R concentrations of GD patients had only the tendency to be higher versus controls, but strong positive correlations between fT3 and fT4 and sIL-2R in peripheral blood of GD subjects were revealed. We showed that sIL-2R was the best cytokine marker, showing very good correlation with the endocrine status of GD patients.

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Citations

Apr 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Keiko TakeokaYoshinori Iwatani
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Nikolaos Pontikides, Gerasimos E Krassas
Sep 17, 2004·Journal of Cellular Biochemistry·Subhashini YaturuSidney R Grimes
Jan 8, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L S Ward, G A Fernandes
Sep 14, 2021·Modern Rheumatology Case Reports·Ichiro KobayashiTadashi Ariga

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