Abstract
In order to examine which cytokine could be used as a marker of the biological effect of thyroid hormones or anti-thyroid antibodies in Graves' disease (GD) patients, we simultaneously evaluated the concentrations of TSH, free thyroid hormones (fT3 and fT4), anti-thyroid antibodies (anti-TPO and anti-TG) and a group of cytokines: interleukin-2 (IL-2), tumour necrosis factor alpha (TNFalpha), interleukin-6 (IL-6) and their soluble receptors (sIL-2R, sTNFalphaR, sIL-6R) as well as interleukin-10 (IL-10) in eight GD females and nine normal controls. We found that serum sIL-2R concentrations of GD patients had only the tendency to be higher versus controls, but strong positive correlations between fT3 and fT4 and sIL-2R in peripheral blood of GD subjects were revealed. We showed that sIL-2R was the best cytokine marker, showing very good correlation with the endocrine status of GD patients.
References
Nov 1, 1992·Internal Medicine·H Kashiwagi, H Suzuki
Jan 1, 1992·Autoimmunity·S Nagataki, K Eguchi
Nov 1, 1992·Clinical Endocrinology·S MariottiA Pinchera
Feb 1, 1992·Immunology Letters·K YasukawaT Kishimoto
Jan 1, 1991·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·C S Balázs
Jan 1, 1991·Digestion·K MitsuyamaK Fujisaki
Oct 15, 1990·Annals of Internal Medicine·L A Rubin, D L Nelson
Jan 1, 1985·Endocrine Reviews·K D Burman, J R Baker
Nov 1, 1980·The International Journal of the Addictions·J Tyler, J R Sheridan
Apr 18, 1980·Science·S Orloff, D Manicourt
May 1, 1994·Neuroimmunomodulation·M PawlikowskiJ Komorowski
Jan 1, 1994·Rheumatology International·M CarottiC Cervini
Jul 1, 1994·Cytokine·U ZornJ Atzpodien
Nov 26, 1993·Deutsche medizinische Wochenschrift·R WagnerD Reinwein
Jan 28, 1994·Cell·T KishimotoS Akira
Jun 27, 1996·The New England Journal of Medicine·F Bazzoni, B Beutler
Dec 1, 1991·Physical Review C: Nuclear Physics·R A LindgrenJ A Carr
Jul 12, 2001·Infection and Immunity·H GuerreiroD A Haake
Jan 1, 1993·Mediators of Inflammation·C CarusoM A Modica
Jan 1, 1996·Mediators of Inflammation·E RobakE Waszczykowsk
Citations
Oct 2, 2002·Clinical Endocrinology·Juan J DíezPedro Iglesias
Apr 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Keiko TakeokaYoshinori Iwatani
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Nikolaos Pontikides, Gerasimos E Krassas
Apr 25, 2001·Clinical Endocrinology·K LewandowskiP O'Hare
Sep 17, 2004·Journal of Cellular Biochemistry·Subhashini YaturuSidney R Grimes
Jan 8, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L S Ward, G A Fernandes
Aug 7, 2007·Endocrine Journal·Carlo CappelliEnrico Agabiti Rosei
Jun 6, 2009·Journal of Endocrinological Investigation·M OzkayaS Simsek Imrek
Sep 14, 2021·Modern Rheumatology Case Reports·Ichiro KobayashiTadashi Ariga