PMID: 6981766Jul 1, 1982Paper

Cytokinetic and cytogenetic effects of some agricultural chemicals on human lymphoid cells in vitro: organophosphates

Mutation Research
R C SobtiC D Pfaffenberger

Abstract

In the present study, cytotoxic, cytostatic and cytogenetic effects of a number of organophosphate pesticides on human lymphoid cells (LAZ-007) in culture have been examined. Cytotoxic effects were dose related and often led to extensive cell kill. The pronounced effects of various organophosphates on the cell-cycle traverse were shown in data based on the enumeration of M1 and M3 metaphases after incubation of cells with BrdU. In cells incubated with 20 micrograms/ml of the various chemicals, the number of M1 metaphases ranged from 6% (R-1303) to 18% (Azodrin) compared to no M1 metaphases in control cultures. The number of M3s in cultures treated with 20 micrograms/ml of the various chemicals tested varied from 0% (Phosdrin) to 7% (parathion) as compared to 17% in control cultures. 11 out of the 14 organophosphates tested, significantly increased the SCE frequency. Of the 9 chemicals tested after metabolic activation by liver microsomal S9 preparation, significant increases in SCE frequency were seen in diazinon-, dimethoate-, Dursban- and Phosdrin-treated cells.

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Citations

Aug 1, 1991·Bulletin of Environmental Contamination and Toxicology·M V Rani, M S Rao
Nov 1, 1988·Bulletin of Environmental Contamination and Toxicology·D S RupaO S Reddi
Mar 31, 2005·Archives of Toxicology·U Undeğer, N Başaran
Oct 15, 1986·Biochemical Pharmacology·L L RadulovicA P Kulkarni
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Jul 1, 1987·Mutation Research·M F LinT C Wang
Feb 1, 1988·Mutation Research·D M SalvadoriW Beçak
Jan 1, 1992·Mutation Research·G MathewM Abdul Rahiman
Oct 1, 1993·Mutation Research·A Z el-Abidin SalamS A Mansour
Aug 1, 1994·Mutation Research·I V JayashreeM Abdul Rahiman
Mar 1, 1995·Mutation Research·B B GollapudiV A Linscombe
Jan 1, 1993·Mutation Research·M Balaji, K Sasikala
Feb 1, 1991·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D S RupaO S Reddi
Jun 1, 1993·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D GeetanjaliP P Reddy
Apr 29, 1998·Mutation Research·J M PluthR J Albertini
Feb 7, 2001·Mutation Research·S Gómez-ArroyoJ De León-Rodríguez
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Dec 27, 2005·Cancer Investigation·Michael C R Alavanja, Matthew R Bonner
Dec 19, 2007·Toxicology and Applied Pharmacology·Juan F MunizG E Kisby

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