Oct 18, 2013

Cytologic changes of ovarian epithelial cancer induced by neoadjuvant chemotherapy

International Journal of Clinical and Experimental Pathology
Yiying WangWenxin Zheng

Abstract

Neoadjuvant chemotherapy (NACT) followed by cytoreduction has now become a part of standard care for patients with advanced ovarian cancer. Cytologic changes of the cancer cells induced by NACT, however, sometimes may cause confusion in terms of pathologic diagnosis and therefore inappropriate management. The objective of this study was to characterize the histologic or cytologic features of the ovarian cancers from those patients who received NACT in order to improve the diagnostic accuracy and reduce unnecessary clinical workup. Specimens from 120 patients with advanced ovarian cancer who received NACT were studied. All 120 cases had either cytologic samples from ascites (n=108) or fine needle aspiration (n=12) and the diagnosis of consistent with cancers of ovarian origin was made prior to NACT. There were 70 (58.3%) patients received subsequent tumor debulking surgery after NACT. The time frame between NACT and debulking surgery ranged from 28 to 65 with an average of 45 days. Among the 70 cases with cytoreductive surgery, 48 cases containing both pre-NACT cytology/histology and subsequent debulking specimens were suitable for the study. All 48 post-NACT ovarian cancers were reviewed and the characteristic pathologic featur...Continue Reading

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Mentioned in this Paper

Necrosis
Fine-needle Biopsy
Giant Cells
Histology Procedure
CDX2 wt Allele
Epithelial Ovarian Cancer
Cytological Techniques
Both Ovaries
Test, Cytology, Digestive
Ovarian Neoplasm

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