Cytologic diagnosis of coccidioidomycosis: Spectrum of findings in Southern Arizona patients over a 10 year period

Diagnostic Cytopathology
F Zahra AlyRobert Klein

Abstract

The largest series examining the cytological diagnosis of coccidioidomycosis was reported more than 20 years ago and only considered fine needle aspiration (FNA) specimens from pulmonary nodules. Since then, there has been a substantial increase in the incidence of the disease in endemic regions. The aims of this study were to examine the spectrum of Coccidioides in all cytologic specimens and detail their diagnostic and clinical features. The prevalence of infection is also examined against temperature and precipitation data. The Department of Pathology database was retrospectively searched for cases diagnosed as coccidioidomycosis. Climate report was obtained from National Weather Service Forecast Office. Statistical analysis was carried out using JMP version 11.2.0. The presence of Coccidiodes was microscopically diverse with immature spherules, variably sized spherules, endosporulating spherules, empty spherules, and ruptured spherules being observed. Bronchoalveolar lavages demonstrated the greatest number of different forms of Coccidioides and were associated with acute inflammatory response. Granulomas were rare and mostly seen in lymph nodes and extra pulmonary sites. A necrotic background with paucity of inflammation w...Continue Reading

References

Nov 1, 1972·American Journal of Clinical Pathology·L M Deppisch, E M Donowho
Mar 1, 1995·Diagnostic Cytopathology·K T Chen
May 1, 1993·American Journal of Clinical Pathology·S S RaabK G Zimmerman
May 5, 2005·The Journal of Infectious Diseases·Benjamin J ParkRana A Hajjeh
Dec 21, 2012·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)

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Citations

Mar 26, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Alexandra Grosse, Claudia Grosse
Apr 20, 2018·Open Forum Infectious Diseases·Fariba M DonovanJohn N Galgiani
Jan 1, 2018·Current Fungal Infection Reports·Spinello AntinoriCarlo Parravicini

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