PMID: 9439890Jan 24, 1998Paper

Cytologic evaluation of conjunctival epithelium using Cytobrush-S: value of slide preparation by ThinPrep technique

Cytopathology : Official Journal of the British Society for Clinical Cytology
T K KobayashiK Tsubota

Abstract

Recent clinical trials have indicated that an automated smear apparatus (ThinPrep process) of sample preparation has great diagnostic sensitivity. In this study, conjunctival brush cytology prepared using the ThinPrep method was applied in ocular surface disorders especially for dry eye status. To assess its diagnostic value in cellular samples, 17 patients with keratoconjunctivitis sicca (KCS) and 10 normal volunteer patients were examined using this technique. Conjunctival cells from normal controls revealed fine chromatin and polyhedral cytoplasm without having keratinized cytoplasm. On the other hand, the cellular samples from KCS revealed increased keratinized cells with pyknotic nuclei. They also contained extremely elongated cells. In KCS patients, the mean number of keratinized cells was significantly higher (34.1 cells/300 cells) than that of the normal control group (0.2 cells/300 cells). In patients with KCS, inflammatory cell counts were also higher than those of normal controls. Conjunctival cytology by means of the ThinPrep method obviously deserves additional trials as an adjunct in the cytology of dry eye states, especially in quantitative ocular evaluation for various ocular lesions.

References

Dec 1, 1977·American Journal of Ophthalmology·P R EgbertD M Maurice
Aug 1, 1990·Ophthalmology·S C PflugfelderS C Tseng
Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·K KapilaK Verma
Sep 1, 1991·American Journal of Clinical Pathology·M L HutchinsonH G Ball
Jan 1, 1991·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·T K KobayashiE Takamura
Sep 1, 1988·The American Journal of Clinical Nutrition·G NatadisastraA Sommer
Feb 1, 1986·Archives of Ophthalmology·J R WittpennA Sommer
Sep 1, 1987·Diagnostic Cytopathology·K KawaguchiT K Kobayashi
Jul 1, 1984·Archives of Ophthalmology·J D Nelson, J C Wright
Dec 1, 1983·Archives of Ophthalmology·J D NelsonJ D Cameron
Jan 1, 1994·Advances in Experimental Medicine and Biology·E TakamuraT Kobayashi
Jan 1, 1993·Cytopathology : Official Journal of the British Society for Clinical Cytology·M V de RojasM S Salorio
Jan 1, 1993·Diagnostic Cytopathology·I Anagnostopoulou-Fotinopoulou, R Rammou-Kinia

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Citations

Oct 6, 1997·Cytopathology : Official Journal of the British Society for Clinical Cytology·T K KobayashiH Nishino
Oct 27, 2009·Journal français d'ophtalmologie·F Brignole-BaudouinC Baudouin
Jan 24, 1998·Cytopathology : Official Journal of the British Society for Clinical Cytology·R E Bonshek

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