Cytologic evaluation of low grade transitional cell carcinoma and instrument artifact in bladder washings

Acta Cytologica
Young Chae ChuJun Kyu Suh

Abstract

To identify key cytologic features for the separation of low grade transitional cell carcinomas (TCCs) from nonneoplastic lesions in bladder washings. The cytomorphologic features of 95 bladder washing specimens showing papillary fragments, which included 50 low grade TCCs and 45 nonneoplastic lesions, were reviewed retrospectively. Bladder washings from low grade TCCs showed papillary and irregular groups of cells with ragged borders, cytoplasmic homogeneity and subtle nuclear changes, such as increased nuclear/cytoplasmic ratio and irregular nuclear border. Bladder washings after instrumentation from nonneoplastic lesions of the bladder showed cellular specimens with cohesive, ball-shaped and papillary clusters with smooth borders lined with a denser-staining cytoplasmic collar. Reactive urothelial cells often displayed loose aggregates with irregular borders but no cytoplasmic collar. In bladder washing cytology, nuclear changes and cytoplasmic homogeneity play a major role in the diagnosis of carcinoma.

Citations

Jun 29, 2011·Diagnostic Cytopathology·S A Thiryayi, D N Rana
Mar 29, 2016·Cancer Cytopathology·Mingjuan L ZhangChristopher J VandenBussche
Feb 23, 2017·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ebru CakirOzgur Cakmak
Jun 20, 2018·Cytopathology : Official Journal of the British Society for Clinical Cytology·Manish RohillaNandita Kakkar
Apr 15, 2021·Journal of the American Society of Cytopathology : JASC·Jocelyn B ChandlerRebecca J Baldassarri

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