PMID: 9416412Jan 7, 1998Paper

Cytologic evaluation of lumpectomy margins in patients with ductal carcinoma in situ: clinical outcome

Annals of Surgical Oncology
C E CoxSanto Nicosia

Abstract

Breast conservation therapy is controversial for ductal carcinoma in situ (DCIS) due to recently reported high recurrence rates. We believe that cytologic evaluation of lumpectomy margins improves efficiency and leads to a lower recurrence rate following lumpectomy for DCIS. A prospectively accrued database of 1255 breast cancer patients at the H. Lee Moffitt Cancer Center and Research Institute was found to have 218 patients with DCIS (17.4%). Of those 218 cases, 114 were treated with lumpectomy, axillary dissection, and radiation therapy; the remaining 104 patients were treated with mastectomy with or without reconstruction. Imprint cytology was used to evaluate all lumpectomy margins. Permanent sections and imprint cytology were reviewed by the same pathologist. All lumpectomy specimens (116 tumors in 114 patients) were evaluated. The median follow up was 57.5 months (range 2-110 months). One hundred and three patients with 104 tumors were selected on the basis of pure DCIS (with or without microinvasion), and treated with lumpectomy, axillary dissection and radiation therapy. Of the 104 tumors utilizing attempted breast conservation therapy, 7 (6.6%) required mastectomy. There were 6 recurrences (6.1%) with a median time fo...Continue Reading

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Citations

Jan 30, 2007·Annals of Surgical Oncology·Neslihan CabiogluFunda Meric-Bernstam
Jan 7, 2017·Annals of Surgical Oncology·Richard J GraySarah Blair
Feb 1, 2003·Plastic and Reconstructive Surgery·Aldona J Spiegel, Charles E Butler
Oct 20, 2010·Journal of the National Cancer Institute. Monographs·Tatyana ShamliyanRobert L Kane
Aug 30, 2013·International Journal of Surgical Oncology·F CorsiD Foschi
Apr 12, 2000·Cancer Control : Journal of the Moffitt Cancer Center·E L DupontC E Cox
Nov 15, 2001·Advances in Anatomic Pathology·E K Millar, A S Leong
Jan 9, 2007·Annals of Surgical Oncology·Edna K ValdesSheldon M Feldman
Jun 29, 2002·Archives of Pathology & Laboratory Medicine·Andrew J CreagerKim R Geisinger
Aug 5, 2000·Current Problems in Cancer·C Holloway
Oct 12, 2004·American Journal of Surgery·Elizabeth WeinbergSanto Nicosia
Feb 8, 2005·The Breast : Official Journal of the European Society of Mastology·M MuttalibH D Sinnett
Nov 26, 2005·Clinics in Laboratory Medicine·Ardeshir Hakam, Ni Ni Khin

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