Abstract
Histiocytic necrotizing lymphadenitis (HNL), also known as Kikuchi-Fujimoto disease, is a benign and self-limiting disease. It is histologically characterized by nodal lesions that show the infiltration of histiocytes, lymphoid cells, myeloid dendritic cells (mDCs), and plasmacytoid dendritic cells (pDCs), along with either apoptotic or karyorrhexic nuclear debris. pDCs have been proposed to be lymphoid early-committed immature DCs which are positive for CD123, CD303, CD68, and HLA-DR but negative for fascin, a mature DC marker, as well as CD13 and CD33,which are mDC markers. In the present study, we analyzed the cytomorphologic features and frequency of pDCs in the lymph nodes of HNL patients. Because the cytologic apprearance of pDCs with Papanicolau staining was quite similar to that of large lymphocytes, immunocytochemistry against CD123 was necessary for the distinction of pDCs. Counting the number of CD123-positive pDCs in the HNL lymph nodes revealed that pDCs more frequently infiltrated the lymph nodes in the setting of HNL than in either reactive lymphadenitis or T and B cell lymphoma. In addition, interestingly, the numberof pDCs did not depend on the age of the HNL lesion, thus suggesting that pDCs are excellent indi...Continue Reading
References
Jun 1, 1990·The American Journal of Surgical Pathology·G A ChamulakB N Nathwani
Jul 1, 1989·American Journal of Clinical Pathology·F FacchettiV J Desmet
Nov 1, 1983·Histopathology·A C FellerH H Wuthe
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·J OlweusF Lund-Johansen
Jul 5, 2001·The American Journal of Pathology·L FarkasF L Jahnsen
Aug 15, 2001·Seminars in Immunology·L GalibertS Vandenabeele
Dec 14, 2002·Human Immunology·Yong-Jun Liu
Dec 14, 2002·Human Immunology·Andrzej DzionekJürgen Schmitz
Apr 5, 2003·Pathology International·Sindy HuHong-Shang Hong
Feb 1, 1958·Acta Haematologica·K LENNERT, W REMMELE
Oct 31, 2003·Virchows Archiv : an International Journal of Pathology·Fabio FacchettiMarco Colonna
Dec 16, 2005·Diagnostic Cytopathology·Koji KishimotoToshiyuki Mitsuya
Jan 19, 2007·Diagnostic Cytopathology·Koji KishimotoToshiyuki Mitsuya
Oct 6, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·M OsbornT S Levine
Jan 1, 2008·Arthritis and Rheumatism·Marco TucciFranco Silvestris
Feb 16, 2008·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Reena RajasekarAlok Srivastava
Jan 15, 2009·American Journal of Clinical Pathology·Monika E PilichowskaGeraldine S Pinkus
Citations
Dec 18, 2013·The New England Journal of Medicine·Alaka RayDaniel F Boyer
Apr 8, 2011·World Journal of Gastroenterology : WJG·Ji Min LeeHyun Joo Choi
Mar 24, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Atsuko TakadaMasaru Kojima
Oct 9, 2014·European Annals of Otorhinolaryngology, Head and Neck Diseases·L LamzafZ Tazi Mezalek
Sep 29, 2011·Diagnostic Cytopathology·Dilip K DasThamradin A Junaid
Feb 22, 2012·Diagnostic Cytopathology·Sara E MonacoLiron Pantanowitz
Jul 20, 2018·Italian Journal of Pediatrics·Mara LeliiSamantha Bosis
Dec 3, 2013·Virchows Archiv : an International Journal of Pathology·Shigeyuki AsanoMasaru Kojima
Jul 16, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Miao WangYan Yang
Oct 2, 2020·The Laryngoscope·Sang Gyu ParkKyung Tae
May 16, 2013·Histopathology·Aaron AuerbachNadine S Aguilera
Dec 20, 2019·Histopathology·Narittee SukswaiJoseph D Khoury
Dec 29, 2020·Clinical Case Reports·Abdul Rahman R HalawaAbdulqadir J Nashwan
Jun 25, 2020·Heliyon·Xiaoyan HuangLijun Zhang
May 18, 2021·Journal of Clinical and Experimental Hematopathology : JCEH·Shigeyuki AsanoHoshiro Suzuki
Sep 7, 2021·Leukemia & Lymphoma·Nathaniel R WilsonNaveen Pemmaraju