Cytologic features and frequency of plasmacytoid dendritic cells in the lymph nodes of patients with histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease)

Diagnostic Cytopathology
Koji KishimotoToshiyuki Mitsuya

Abstract

Histiocytic necrotizing lymphadenitis (HNL), also known as Kikuchi-Fujimoto disease, is a benign and self-limiting disease. It is histologically characterized by nodal lesions that show the infiltration of histiocytes, lymphoid cells, myeloid dendritic cells (mDCs), and plasmacytoid dendritic cells (pDCs), along with either apoptotic or karyorrhexic nuclear debris. pDCs have been proposed to be lymphoid early-committed immature DCs which are positive for CD123, CD303, CD68, and HLA-DR but negative for fascin, a mature DC marker, as well as CD13 and CD33,which are mDC markers. In the present study, we analyzed the cytomorphologic features and frequency of pDCs in the lymph nodes of HNL patients. Because the cytologic apprearance of pDCs with Papanicolau staining was quite similar to that of large lymphocytes, immunocytochemistry against CD123 was necessary for the distinction of pDCs. Counting the number of CD123-positive pDCs in the HNL lymph nodes revealed that pDCs more frequently infiltrated the lymph nodes in the setting of HNL than in either reactive lymphadenitis or T and B cell lymphoma. In addition, interestingly, the numberof pDCs did not depend on the age of the HNL lesion, thus suggesting that pDCs are excellent indi...Continue Reading

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Citations

Apr 8, 2011·World Journal of Gastroenterology : WJG·Ji Min LeeHyun Joo Choi
Mar 24, 2017·Journal of Clinical and Experimental Hematopathology : JCEH·Atsuko TakadaMasaru Kojima
Oct 9, 2014·European Annals of Otorhinolaryngology, Head and Neck Diseases·L LamzafZ Tazi Mezalek
Feb 22, 2012·Diagnostic Cytopathology·Sara E MonacoLiron Pantanowitz
Jul 20, 2018·Italian Journal of Pediatrics·Mara LeliiSamantha Bosis
Dec 3, 2013·Virchows Archiv : an International Journal of Pathology·Shigeyuki AsanoMasaru Kojima
Jul 16, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Miao WangYan Yang
Dec 29, 2020·Clinical Case Reports·Abdul Rahman R HalawaAbdulqadir J Nashwan
Sep 7, 2021·Leukemia & Lymphoma·Nathaniel R WilsonNaveen Pemmaraju

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