PMID: 9181313Jun 1, 1997Paper

Cytologic features of post-transplant lymphoproliferative disorder

Diagnostic Cytopathology
D DusenberyS H Swerdlow

Abstract

Post-transplant lymphoproliferative disorders (PTLD) are Epstein-Barr virus (EBV)-associated lymphoid proliferations which affect approximately 2% of organ allograft recipients. Although the histologic features of PTLD are well described, they have been described only rarely in cytologic specimens. The cytomorphologic features of PTLD in body fluid specimens, needle aspirations, and a gastric brushing specimen from seven patients with histologically confirmed PTLD were therefore reviewed. In the cytologic specimens, PTLD was characterized by a mostly polymorphous population of lymphoid cells containing many large transformed lymphocytes, occasional immunoblast-like atypical lymphocytes, necrosis, and, frequently, obvious plasmacytoid differentiation. The presence of EBV was documented in five of the seven cases in the corresponding tissue biopsies. The four patients with PTLD in a body fluid specimen all died within 3 months of detection of the PTLD in the body fluid. The three remaining patients are alive with resolution of PTLD (follow-up of 7, 8, and 14 months). The diagnosis of PTLD should be suggested when cytologic specimens from organ allograft recipients show a polymorphous atypical lymphoid proliferation, frequently wi...Continue Reading

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Citations

Nov 17, 2006·Leukemia & Lymphoma·Becky van Ells, John Lazarchick
Sep 3, 2005·Diagnostic Cytopathology·Paolo Gattuso, Frances Manosca
Dec 31, 1998·Springer Seminars in Immunopathology·M A Nalesnik
May 3, 2012·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Morteza Izadi, Saeed Taheri
Nov 1, 2017·Case Reports in Hematology·Harsh D Patel, Moises I Nevah Rubin
Mar 7, 2001·Archives of Pathology & Laboratory Medicine·H HoffmannL J Medeiros

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