Cytologic findings in minimal deviation adenocarcinoma (adenoma malignum) of the cervix. A report of seven cases

American Journal of Clinical Pathology
S R Granter, K R Lee

Abstract

Minimal deviation adenocarcinoma (MDA) is a rare extremely well-differentiated form of invasive cervical adenocarcinoma. Because of its rarity and perhaps because cytologic changes are subtle and may be missed, there are only a few reports that illustrate the cytologic features of this neoplasm. To better understand the presentation of MDA in cervical smears and the role of cytology in diagnosing this lesion, the authors reviewed the clinical, histologic, and cytologic finding in seven patients. In two cases, MDA was an incidental finding in the a hysterectomy specimen. Three patients had a vaginal discharge and one patient had a "beefy red" cervix noted on pelvic examination. Although all 7 patients had cervical smears taken within 1 to 17 months before biopsy, in only one of the patients did the cervical smear lead to the diagnosis. On review, all smears from four patients were considered normal. In six smears from the remaining three patients, there were abnormal glandular cells that ranged from atypical to suspicious for well-differentiated adenocarcinoma in retrospect. All of these patients had minor foci of less well-differentiated carcinoma in their tumors. In 11 smears from 5 patients, including the smears with diagnost...Continue Reading

Citations

Sep 12, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·D JuricD Buković
May 10, 2011·Clinical Nuclear Medicine·Hadley J SharpPedro T Ramirez
Jul 15, 2015·Diagnostic Cytopathology·Fumi KawakamiTomoo Itoh
Oct 2, 2013·CytoJournal·Walid E KhalbussSara E Monaco
Sep 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·William R Hart
Aug 31, 2002·Diagnostic Cytopathology·Sakae HataToshiaki Manabe
Nov 9, 2007·The British Journal of Radiology·K Sugiyama, Y Takehara
Feb 27, 2019·Journal of Gynecology Obstetrics and Human Reproduction·Lucie BoninFrançois Golfier

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