Cytologic-histologic concordance in the diagnosis of neoplasia in canine and feline lymph nodes: a retrospective study of 367 cases

Veterinary and Comparative Oncology
C-K KuM M Christopher


Lymph nodes are frequently sampled in dogs and cats for the diagnosis of primary and metastatic neoplasia. We determined the accuracy of cytologic diagnosis in lymph nodes using histology as the gold standard. Lymph node reports (2001-2011) were retrospectively evaluated and diagnoses were categorized as neoplastic or non-neoplastic. Lymph nodes from 296 dogs and 71 cats included 157 (42.7%) non-neoplastic lesions, 62 (16.9%) lymphomas and 148 (40.3%) metastatic neoplasms. Cytology had a sensitivity of 66.6% [95% confidence interval (CI) 60.0-72.8%], specificity of 91.5% (CI 86.3-95.2%), and accuracy of 77.2% (CI 72.6-81.3%) for neoplasia. Likelihood of malignancy with a positive cytologic diagnosis of neoplasia was 93.0%. High proportions of false-negative results were found in mesenteric T-cell lymphoma (22/35, 63%, mainly cats), metastatic sarcoma (8/14, 57%) and metastatic mast cell tumour (15/48, 31%, mainly dogs). Factors contributing to discrepancies included well-differentiated lymphocyte morphology, focal distribution of metastases and poorly defined criteria for metastatic mast cell tumours.


May 10, 2001·Journal of the American Veterinary Medical Association·A LangenbachK U Sorenmo
Apr 11, 2003·Journal of the American Veterinary Medical Association·Michele CohenJoseph S Spano
May 3, 2003·Journal of the American Veterinary Medical Association·Laurel E Williams, Rebecca A Packer
Mar 6, 2007·The Veterinary Clinics of North America. Small Animal Practice·Leslie C SharkeyMichael E Matz
May 21, 2009·Veterinary and Comparative Oncology·E L KrickK U Sorenmo
Feb 8, 2011·Clinics in Laboratory Medicine·Dorothee Bienzle, William Vernau
Jul 20, 2012·Journal of Feline Medicine and Surgery·Kieran J RussellVanessa R Barrs
Jan 22, 2014·Journal of the American Animal Hospital Association·Heather BaginskiRichard P Bastian
Dec 9, 2014·The Journal of Small Animal Practice·I Amores-FusterL Blackwood

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