Cytologic-histologic concordance in the diagnosis of neoplasia in canine and feline lymph nodes: a retrospective study of 367 cases

Veterinary and Comparative Oncology
C-K KuM M Christopher

Abstract

Lymph nodes are frequently sampled in dogs and cats for the diagnosis of primary and metastatic neoplasia. We determined the accuracy of cytologic diagnosis in lymph nodes using histology as the gold standard. Lymph node reports (2001-2011) were retrospectively evaluated and diagnoses were categorized as neoplastic or non-neoplastic. Lymph nodes from 296 dogs and 71 cats included 157 (42.7%) non-neoplastic lesions, 62 (16.9%) lymphomas and 148 (40.3%) metastatic neoplasms. Cytology had a sensitivity of 66.6% [95% confidence interval (CI) 60.0-72.8%], specificity of 91.5% (CI 86.3-95.2%), and accuracy of 77.2% (CI 72.6-81.3%) for neoplasia. Likelihood of malignancy with a positive cytologic diagnosis of neoplasia was 93.0%. High proportions of false-negative results were found in mesenteric T-cell lymphoma (22/35, 63%, mainly cats), metastatic sarcoma (8/14, 57%) and metastatic mast cell tumour (15/48, 31%, mainly dogs). Factors contributing to discrepancies included well-differentiated lymphocyte morphology, focal distribution of metastases and poorly defined criteria for metastatic mast cell tumours.

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Citations

Jul 27, 2018·Veterinary and Comparative Oncology·Laura MarconatoSilvia Sabattini
Feb 15, 2020·Veterinary Sciences·Simonetta CitiMannucci Tommaso
May 18, 2019·Archives of Pathology & Laboratory Medicine·Kenneth P H Pritzker, Heikki J Nieminen
Oct 12, 2018·BMC Veterinary Research·Mathieu V PaulinValérie Freiche
Sep 10, 2020·Frontiers in Veterinary Science·Michael CongiustaStephanie Goldschmidt
Jan 16, 2021·The Veterinary Clinics of North America. Small Animal Practice·Janis Lapsley, Laura E Selmic
Apr 23, 2021·Veterinary and Comparative Oncology·Lavinia E ChitiRoberta Ferrari
Jul 10, 2021·Veterinary and Comparative Oncology·Sohee BaeMilan Milovancev
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Roberta FerrariDamiano Stefanello
Oct 5, 2021·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sophie FavrilKatrien Vanderperren

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