Cytologic malignancy versus benignancy: how useful are the "newer" markers in body fluid cytology?

Archives of Pathology & Laboratory Medicine
Virganeyce Lyons-BoudreauxDonna Coffey

Abstract

Differentiating reactive effusion, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids can be challenging. Interpreting immunohistochemical markers in cell block preparations can be difficult because of nonspecific staining, focal staining, or poor staining quality. We selected a panel of conventional and newer markers to assess their utility in evaluating effusions. To evaluate the efficacy of 5 immunohistochemical markers in the differential diagnosis of reactive mesothelial proliferation, malignant mesothelioma, and metastatic adenocarcinoma in body cavity fluids. A total of 72 formalin-fixed, paraffin-embedded cell block specimens from pleural and peritoneal effusions, including 5 mesotheliomas, 48 adenocarcinomas, and 19 benign effusions were stained with antibodies against calretinin, D2-40, XIAP, MOC-31, and WT1. All benign effusions and mesotheliomas demonstrated diffuse membranous staining with D2-40. All mesotheliomas displayed calretinin positivity, whereas only 58% of benign effusions stained focally with calretinin. MOC-31 was positive in all cases of adenocarcinoma, whereas all benign effusions and mesotheliomas were negative. All cases of the metastatic adenocarcinoma were negative for cal...Continue Reading

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Citations

Mar 7, 2021·Diagnostic Cytopathology·Wadad S MneimnehClaire W Michael
May 7, 2009·Archives of Pathology & Laboratory Medicine·Oscar Lin
Feb 24, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yukio TakeshimaTakumi Kishimoto
Apr 25, 2009·Applied Immunohistochemistry & Molecular Morphology : AIMM·Reetesh K Pai, Robert B West
Jan 6, 2010·Diagnostic Cytopathology·Nidhi Sharma, Pranab Dey
Mar 17, 2010·Diagnostic Cytopathology·Viktor ShtilbansDavid E Burstein
Jun 22, 2010·American Journal of Industrial Medicine·Takumi KishimotoKohki Inai
Dec 17, 2010·World Journal of Cardiology·Chiara Lestuzzi
Mar 26, 2011·Pathology·Steven Chuan-Hao KaoSonja Klebe
Mar 31, 2011·British Journal of Cancer·S van der BijK G M Moons
Sep 10, 2009·Southern Medical Journal·John GriniatsosMichalis Tzivras

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