PMID: 9439892Jan 24, 1998Paper

Cytological aspects of uterine cervical adenocarcinoma, adenosquamous carcinoma and combined adenocarcinoma-squamous carcinoma: appraisal of diagnostic criteria for in situ versus invasive lesions

Cytopathology : Official Journal of the British Society for Clinical Cytology
M M HayesR Amy

Abstract

This paper reports the cytological findings based on air-dried smears in a retrospective series of 143 cases of endocervical adenocarcinoma, combined adenocarcinoma-squamous carcinoma and adenosquamous carcinoma drawn from the files of the BC Cancer Registry. Cervical cytology smears were available before biopsy in 131 patients, but in 18 cases the cytology showed no abnormality. Malignant changes or high-grade atypia of glandular and/or squamous cells (defined as moderate or severe dyskaryosis) were detected in 103 cases. In 46 cases, only a high-grade squamous abnormality was detected. Low-grade glandular and/or squamous lesions were detected in nine cases and one showed atypical endometrial-type glands. The cervical smears of 64 cases were reviewed in detail to determine the important cytomorphological criteria of in situ and invasive adenocarcinoma in air-dried smears, the technique used for preparing PAP smears in British Columbia. Endocervical cells were absent in four cases. Numerous (> 10) groups of glandular cells were present in 51 cases. Important clues to the diagnosis of adenocarcinoma included crowding of nuclei, stratification of nuclei, loss of polarity, syncytial balls and papillary groups of glandular cells, n...Continue Reading

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Citations

Jan 22, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·S H Rabelo-SantosL C Zeferino
Oct 16, 2010·Diagnostic Cytopathology·Yashwant KumarSeema Sharma
Oct 11, 2011·Vaccine·Muhieddine SeoudVeerle Ronsse
Aug 4, 2018·Journal of Lower Genital Tract Disease·Wen ChenUNKNOWN Chinese HPV Typing Group

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