PMID: 6159264Jan 1, 1980Paper

Cytological characteristics of erythropoiesis in thalassemia. I. Functional characteristics of the nucleated elements of erythropoiesis in the bone marrow

Folia haematologica : internationales Magazin für klinische und morphologische Blutforschung
G I KosinetzT A Mamedowa

Abstract

In 24 patients affected with thalassaemia of various degrees of seriousness the functional condition of nuclear cells or red serie was investigated in the bone-marrow. The investigation was carried out by analyzing partial erythroblastogrammes, evaluating proliferative activity according to the 3H-thymidine marking index and determining ineffective erythropoiesis by means of nucleated PAS-positive erythroblasts. The findings reveal the degree of seriousness of the disease being directly dependent on the extent of functional disturbances in the cells of the erythropoietic system.

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