Cytological features of cystadenocarcinoma in cyst fluid of the parotid gland: Diagnostic pitfalls and literature review

Diagnostic Cytopathology
Akihiko KawaharaMasayoshi Kage

Abstract

Cystadenocarcinoma is a rare malignant tumor, with an estimated incidence of 2% of malignant salivary gland tumors. Cytological diagnosis of cystadenocarcinoma is important for differential diagnosis between benign lesions and malignant tumors with cystic growth. We report a case of cystadenocarcinoma causing difficulty in cytological diagnosis. A 23-year-old man presented with an asymptomatic mass in the left parotid gland that had been present for 2 years. The mass was elastic hard, measuring 30 x 35 mm in diameter. Preoperative fine-needle aspiration cytology (FNAC) showed a small number of tumor cell clusters in the cystic fluid. The cluster was arranged in a ball-like structure and was cohesive with overlapping. Tumor cells had a small vacuolated, soap-bubble appearance in the cytoplasm. The papillary-cystic variant of acinic cell carcinoma (ACC-PCV) was suggested from these findings on FNAC. Histologically, the tumor was not encapsulated, but formed large cystic spaces against a background of fibrous connective tissue. The tumor cells in the cystic dilated duct showed papillary structures, which were continuous with the lining cuboidal cells. There was neither a definite double-layered arrangement in cystic ducts and soli...Continue Reading

References

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Jul 12, 2002·Diagnostic Cytopathology·Kusum Kapila, Kusum Verma
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Jun 1, 2005·Auris, Nasus, Larynx·Erdinc AydinBabur Akkuzu
Aug 2, 2005·International Journal of Oral and Maxillofacial Surgery·M ToidaT Shibata
Feb 2, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·N J JohnstonM J Lutterloch
Apr 25, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Hirofumi TomiokaKen Omura
Oct 19, 2006·Auris, Nasus, Larynx·Roberta Barroso CavalcanteLélia Batista de Souza

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Citations

Jun 25, 2014·Case Reports in Ophthalmological Medicine·Miles Bannister, Greig Lawson
Aug 10, 2019·Diagnostic Cytopathology·Siba El Hussein, Samer N Khader

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