Cytological grading of breast carcinoma--a feasible proposition?

Cytopathology : Official Journal of the British Society for Clinical Cytology
C M HuntR W Blamey

Abstract

Fine needle aspiration cytology (FNAC) of the breast is widely used in the diagnosis of breast carcinoma. In some centres this is sometimes the only diagnostic procedure performed prior to definitive treatment. A grading system based on cytology would be helpful in the selection of patients for appropriate therapy. The aim of this study, therefore, was to devise such a system for grading breast carcinoma based on cytological features alone. The features assessed were the degree of cell clustering, nuclear pleomorphism, nuclear diameter, the presence of multiple, easily visible nucleoli and necrosis. Cytological features were compared to the histological grade of the tumours following excision. Discriminant analysis showed that the features with the closest correlation with histological grade were nuclear diameter, nuclear pleomorphism and the presence of nucleoli. A scoring system based on these three parameters enabled the classification of tumours into high and low cytological grades which showed a close correlation with histological grade.

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Citations

Mar 1, 1995·Diagnostic Cytopathology·I Robinson, G McKee
Dec 1, 1995·Diagnostic Cytopathology·S Masood
May 9, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M SuzukiN Nakajima
Oct 3, 2006·European Radiology·Matthew WallisUNKNOWN European Society of Breast Imaging
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Nov 26, 2005·Clinics in Laboratory Medicine·Shahla Masood
Dec 15, 2004·Cancer·Yukari NishimuraHiroyuki Kuramoto
Oct 20, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·T Sauer, M Karimzadeh
Apr 4, 2015·South Asian Journal of Cancer·Jyoti Prakash PhukanJatindra Prasad Deka
Mar 9, 1999·Cytopathology : Official Journal of the British Society for Clinical Cytology·J Keeling, G T McKee
Mar 21, 2001·Cytopathology : Official Journal of the British Society for Clinical Cytology·B SkrbíncM Us-Krásovec
Oct 1, 1996·Cytopathology : Official Journal of the British Society for Clinical Cytology·C M HuntI O Ellis
Apr 1, 1995·Cytopathology : Official Journal of the British Society for Clinical Cytology·I Robinson, G McKee
Oct 1, 1994·Cytopathology : Official Journal of the British Society for Clinical Cytology·H de GraafW J Sluiter
Jan 1, 1992·Cytopathology : Official Journal of the British Society for Clinical Cytology·R D StartJ H Smith
Jan 1, 1991·Cytopathology : Official Journal of the British Society for Clinical Cytology·A HitchcockI O Ellis
Sep 12, 2019·Frontiers in Veterinary Science·Krithiga KuppusamyPriya Srinivas

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