Cytologically low grade malignancies: an important interpretative pitfall responsible for false negative diagnoses in fine-needle aspiration of the breast

Diagnostic Cytopathology
L J Layfield, L G Dodd

Abstract

Failure to diagnose breast carcinoma by fine-needle aspiration (FNA) is a major obstacle to expanded use of that technique. While the majority of false negative diagnoses are due to inadequate sampling and insufficient specimens, a significant minority of false negative cases result from inaccurate interpretation of adequate material. Low grade carcinomas including lobular, tubular, low grade adenosquamous, and papillary carcinomas appear to account for many of these diagnostic errors. Careful attention to nuclear detail, monomorphism of cell population and the presence of neoplastic cells with retained cytoplasm should allow the recognition of the majority of these neoplasms as malignant by cytologic examination.

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Citations

Jun 24, 2004·Cancer·Rima KanhoushParvin Ganjei-Azar
May 4, 2011·Diagnostic Cytopathology·Maria SironiFrancesca Saro
Dec 27, 2012·Journal of Clinical Pathology·Kailing Soo, Puay Hoon Tan
Jan 31, 2006·São Paulo Medical Journal = Revista Paulista De Medicina·Ruffo Freitas JúniorRegis Resende Paulinelli
Jun 21, 2006·Journal of Magnetic Resonance Imaging : JMRI·Erika RubesovaMarc Lemort
Jul 17, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·M Karimzadeh, T Sauer
Feb 12, 2011·Orvosi hetilap·Mihály BakMiklós Kásler
Jun 11, 2011·Ultrastructural Pathology·Aasmund Berner, Torill Sauer
Apr 14, 2000·Cancer Control : Journal of the Moffitt Cancer Center·N N KuS V Nicosia
Nov 18, 2000·Archives of Pathology & Laboratory Medicine·T Myers, H H Wang

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