Abstract
Univariate analyses on malignant salivary gland tumors report a strong relation of histological subtypes and prognosis. However, multivariate analyses with sufficient patients and reflecting the broad spectrum of putative prognostic factors are rare. In order to study the prognostic value of cytology and histology in salivary carcinoma we performed multivariate analyses on 666 newly diagnosed patients. In multivariate analyses sex, tumor size, N- and M-staging, localization, comorbidity, skin involvement and pain were independent predictors of survival. Histology was an independent prognostic factor, mainly because acinic cell carcinoma acted differently from the other histological subtypes. However, a simple prognostic model without cytology and/or histology has similar predictive power compared to more elaborate models. The added prognostic value of cytology and/or histology factors in salivary carcinoma is limited, largely due to the combined prognostic value of other prognostic factors such as tumor size, N- and M-classification and comorbidity.
References
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·M G PoulsenL B Tripcony
Nov 1, 1991·Archives of Otolaryngology--head & Neck Surgery·R A FrankenthalerH Goepfert
Mar 1, 1991·Archives of Otolaryngology--head & Neck Surgery·W J KaneJ E Lewis
Mar 1, 1989·Archives of Otolaryngology--head & Neck Surgery·R H SpiroE W Strong
Dec 1, 1986·American Journal of Clinical Oncology·C Theriault, P J Fitzpatrick
Jun 1, 1996·International Journal of Radiation Oncology, Biology, Physics·J T ParsonsR R Million
Feb 28, 1996·Statistics in Medicine·F E HarrellD B Mark
Dec 1, 1996·The British Journal of Surgery·A RenehanM McGurk
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·A S GardenL J Peters
Oct 28, 1998·Head & Neck·M A LopesL P Kowalski
Nov 21, 1998·The Annals of Otology, Rhinology, and Laryngology·C CalearoG Polli
Sep 25, 2001·The Laryngoscope·E HocwaldJ R Jacobs
Dec 11, 2002·Clinical Otolaryngology and Allied Sciences·G HarboJ Overgaard
Aug 3, 2004·Head & Neck·Chris H J TerhaardUNKNOWN Dutch Head and Neck Oncology Cooperative Group
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Chris H J TerhaardUNKNOWN Dutch Head and Neck Oncology Cooperative Group
Jan 7, 2005·American Journal of Otolaryngology·Neil Bhattacharyya, Marvin P Fried
Jul 9, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R Bryan BellBryce E Potter
Nov 9, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Roberto A LimaScheylla Salviano
Sep 5, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chris TerhaardPaul Knegt
Apr 6, 2007·Cancer·José F CarrilloLuis F Oñate-Ocaña
Sep 11, 2007·Oral Oncology·A V JonesC D Franklin
Nov 22, 2007·The Laryngoscope·Katri AroAntti A Mäkitie
Aug 16, 2008·Cancer·Chris H J TerhaardRobert J Baatenburg de Jong
Citations
Aug 19, 2011·Der Pathologe·S Schwarz-Furlan
Jul 31, 2012·Oral and Maxillofacial Surgery·Tobias EttlTorsten E Reichert
Apr 5, 2016·Otolaryngologic Clinics of North America·Aaron G LewisEllie Maghami
Mar 25, 2015·Journal of Cancer Research and Clinical Oncology·Orlando Guntinas-LichiusHarald Schmalenberg
Jul 16, 2013·Oral Oncology·Matthias KreppelDirk Beutner
Mar 17, 2016·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Matthew MifsudJimmy Caudell
Sep 29, 2018·Cancer Cytopathology·Esther Diana Rossi, William C Faquin
Aug 25, 2016·Cancer Control : Journal of the Moffitt Cancer Center·Matthew J MifsudTapan A Padhya
Mar 19, 2021·Head & Neck·Marie Westergaard-NielsenKristine Bjørndal