Cytology and human papillomavirus co-test results preceding incident high-grade cervical intraepithelial neoplasia

PloS One
Ina U ParkM Michele Manos

Abstract

High-risk HPV (hrHPV) and cytology co-testing is utilized for primary cervical cancer screening and for enhanced follow-up of women who are hrHPV-positive, cytology negative. However, data are lacking on the utility of this method to detect pre-cancer or cancer in community-based clinical practice. This study describes cytology and hrHPV results preceding high-grade cervical intraepithelial neoplasia, adenocarcinoma in situ, or cervical cancer (i.e., CIN2+) in an integrated health system employing routine co-testing among women aged 30 years and older. We conducted a cross-sectional analysis of adult female members of Kaiser Permanente Northern California (KPNC) with incident CIN2+ between July 2008 and June 2009. The primary outcome was the proportions of cytologic diagnoses and hrHPV co-test results preceding a diagnosis of CIN2+. Cervical cytology and hrHPV testing results were abstracted from electronic medical records. Of 1283 CIN2+ cases among adult women, 880 (68.5%) were among women aged 30 years and older and 145/880 (16.5%, 95% CI 14.1-19.1) had only normal cytology during the 12 months prior to diagnosis. Furthermore, 133/880 (15.1%, 95% 12.9-17.7) were preceded by only normal cytology and persistent hrHPV infection ...Continue Reading

References

May 11, 1999·JAMA : the Journal of the American Medical Association·M M ManosR A Hiatt
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
May 22, 2007·Clinical Obstetrics and Gynecology·Thomas C Wright
Jul 27, 2007·Preventive Medicine·Andrea R SpenceEduardo L Franco
Oct 2, 2007·American Journal of Obstetrics and Gynecology·Thomas C WrightUNKNOWN 2006 American Society for Colposcopy and Cervical Pathology-sponsored Consensus Conference
Oct 6, 2007·Journal of Lower Genital Tract Disease·Thomas C WrightUNKNOWN 2006 American Society for Colposcopy and Cervical Pathology-sponsored Consensus Conference
Oct 19, 2007·The New England Journal of Medicine·Pontus NauclerJoakim Dillner
Jan 1, 2008·Obstetrics and Gynecology·Marc ArbynJohan Bulten
Dec 24, 2008·Obstetrics and Gynecology·Philip E CastleDiane Solomon
Oct 29, 2009·JAMA : the Journal of the American Medical Association·Albertus G SiebersMarc Arbyn
Nov 27, 2009·The New England Journal of Medicine·George F Sawaya
Jan 22, 2010·The Lancet Oncology·Guglielmo RoncoUNKNOWN New Technologies for Cervical Cancer screening (NTCC) Working Group
Mar 27, 2013·Journal of Lower Genital Tract Disease·L Stewart MassadUNKNOWN 2012 ASCCP Consensus Guidelines Conference

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Citations

Mar 6, 2017·Oncology Reports·Sai HanYouzhong Zhang

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Methods Mentioned

BETA
DNA assay
biopsy

Software Mentioned

STATA

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