PMID: 11933264Apr 5, 2002Paper

Cytology of primary central nervous system neoplasms in cerebrospinal fluid specimens

Diagnostic Cytopathology
David C ChhiengJoan F Cangiarella

Abstract

Although two-thirds of tumors occurring in the central nervous system (CNS) are primary neoplasms, only 10% of positive cerebrospinal fluid (CSF) specimens are from primary CNS tumors. In this study, we reviewed the cytologic findings of 21 positive CSF specimens from primary CNS tumors. A computer search identified 21 cases of positive CSF specimens from patients with primary CNS tumors from the archives. Follow-up included review of medical charts and histologic correlation. The specimens were from 20 patients (9 females and 11 males). Their ages ranged from 6-83 yr, old with a mean of 30 yr. The cases included 9 medulloblastomas, 7 gliomas (3 glioblastoma multiformes, 2 anaplastic astrocytomas, and 2 ependymomas), 2 germinomas, 2 non-Hodgkin's large B-cell lymphomas, and 1 ganglioneurocytoma. Two cases were classified as suspicious and the remaining as positive for malignancy. Immunocytochemistry was employed in 3 cases to support the cytologic diagnosis. These cases included one large-cell lymphoma (leukocyte-common antigen-positive), one germinoma (placental alkaline phosphatase-positive), and the ganglioneurocytoma (neuron-specific enolase- and synaptophysin-positive). There were no false-positive cases. Our results sugge...Continue Reading

References

May 1, 1992·Journal of Neuropathology and Experimental Neurology·S H Bigner
Oct 1, 1985·Cancer·M S EdwardsJ P Laurent
Apr 1, 1968·Journal of Neurosurgery·M el-Batata
Aug 1, 1974·The Journal of Pediatrics·A S AronsonR Sörnäs
Jan 1, 1993·Diagnostic Cytopathology·A T MoriartyD W McCloskey

❮ Previous
Next ❯

Citations

May 29, 2012·Current Oncology Reports·Erick Crespo-SolisBeatriz Vega-Ramos
Oct 12, 2005·Journal of Pediatric Hematology/oncology·Yusuke ShiozawaYuichiro Yamashiro
Nov 9, 2007·Pathology International·Akira KuroseTakashi Sawai
Nov 30, 2014·Neurosurgery Clinics of North America·Phillip A BonneyMichael E Sughrue
Jan 30, 2004·Cytopathology : Official Journal of the British Society for Clinical Cytology·R K GuptaR Fauck
Jul 16, 2011·Diagnostic Cytopathology·Christina PerskeHerwig Strik
Oct 31, 2014·Diagnostic Cytopathology·Jennifer P BynumSyed Z Ali
Apr 5, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·D AtesF Soylemezoglu
Jan 23, 2015·Diagnostic Cytopathology·Melanie J Kubik, Jinous Saremian
Jun 29, 2016·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Alexandra KalogerakiSavvas Papadopoulos
Oct 4, 2005·Pediatric Blood & Cancer·Igor M Poltinnikov, Thomas E Merchant
Aug 31, 2012·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Elisa PomeroDonatella Tampieri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.