Cytology versus HPV testing for the detection of high-grade cervical lesions in women found positive on visual inspection in Mumbai, India

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Sharmila PimpleSurendra S Shastri

Abstract

To compare the utility of cytology and HPV testing in women from Mumbai, India, suspected of having cervical intraepithelial neoplasia (CIN) on visual inspection with acetic acid (VIA), Lugol's iodine (VILI), or both. The sensitivity, specificity, and predictive values of these tests for the detection of CIN 2 and/or 3 were evaluated in this cross-sectional study with 756 women suspected of having CIN on visual inspection. There were 25 women with CIN 2, 20 with CIN 3, and 21 with invasive cancer. The sensitivity to detect CIN 3 lesions was 85.0% (95% CI, 62.1-96.8) and 70.0% (95% CI, 45.7-88.1) for cytology testing at the ASCUS and LSIL thresholds, respectively, and it was 89.5% (95% CI, 66.9-98.7) for HPV testing. The specificity to detect CIN 3 lesions was 94.5% (95% CI, 92.5-96.1) and 96.1% (95% CI, 94.4-97.5) for cytology testing at the ASCUS and LSIL thresholds, and it was 91.1% (95% CI, 88.5-93.2) for HPV testing. Cytology and HPV testing were both found to be accurate triaging methods for women suspected of having CIN on visual inspection, especially for those with CIN 3 lesions.

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Citations

Nov 9, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R SankaranarayananY Qiao
Jan 17, 2012·Hematology/oncology Clinics of North America·Daniel Echelman, Sarah Feldman
Nov 15, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Rengaswamy SankaranarayananJean-Marie Dangou

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