PMID: 6165690Jul 15, 1980Paper

Cytolytic activity against tumor cells by macrophage cell lines and augmentation by macrophage stimulants

International Journal of Cancer. Journal International Du Cancer
T Taniyama, H T Holden

Abstract

Previous studies have shown that macrophage cell lines retained the ability to phagocytize, to secrete lysosomal enzymes, and to function as effector cells in antibody-dependent cellular cytoxicity. In this paper, the cytolytic activity of murine macrophage cell lines against tumor target cells was assessed using an 18-h 51Cr release assay. Of the macrophage cell lines tested, RAW 264, PU5-1.8 and IC-21 had intermediate to high levels of spontaneous cytolytic activity, P388D, and J774 had low to intermediate levels, while /WEHI-3 showed little or no cytolytic activity against RBL-5, MBL-2 and TU-5 target cells. Tumor-cell killing by macrophage cell lines could be augmented by the addition of macrophage stimulants, such as bacterial lipopolysaccharide and poly I:C, indicating that the activation of macrophages by these stimulants does not require the participation of other cell types. Treatment with interferon also augmented the tumor-cell killing by macrophage cell lines. Although the mechanism by which these cell lines exert their spontaneous or boosted cytotoxic activity is not clear, it does not appear to be due to depletion of nutrients since cell lines with high metabolic and proliferative activities, such as WEHI-3 and RB...Continue Reading

References

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Citations

Jul 14, 1998·In Vitro Cellular & Developmental Biology. Animal·A A BeharkaS K Chapes
May 1, 1990·The Journal of protozoology·K Fischer-StengerF Marciano-Cabral
Aug 15, 1998·The Journal of Eukaryotic Microbiology·F Marciano-Cabral, D M Toney
Jan 15, 1981·International Journal of Cancer. Journal International Du Cancer·R S KerbelH F Pross
Sep 15, 1982·International Journal of Cancer. Journal International Du Cancer·R H WiltroutH T Holden

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