Cytolytic activity and associated serine protease expression by skin and afferent lymph CD8+ T cells during orf virus reinfection

The Journal of General Virology
D M HaigH W Reid

Abstract

Following orf virus reinfection in sheep, CD8+ T cells were recruited to the lesion site in the skin during the period of viral replication and appeared in increased numbers in afferent lymph draining the infection site. A proportion of the CD8+ T cells were activated, particularly in the skin, as determined by their expression of the cytolytic cell-associated serine protease, BLT-esterase. This was a useful marker for activated cytolytic cells as there was a good correlation between afferent lymph CD8+ T cell-mediated lysis of autologous orf virus-infected skin cells and their expression of BLT-esterase in vitro. The majority of the cells that expressed BLT-esterase in the skin and lymph were CD8+ T cells and cytolysis in vitro was predominately by the MHC class I antigen presentation pathway. The conclusion is that orf virus reinfection is characterized by limited viral replication and stimulation of an activated CTL response in the skin.

Citations

Nov 28, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O WeberH-D Volk
Jun 20, 2002·Veterinary Immunology and Immunopathology·David M HaigStephen Fleming
Dec 30, 1999·Veterinary Immunology and Immunopathology·D M Haig, S Fleming
Sep 26, 2002·Virus Research·David M Haig, Colin J McInnes
Jan 26, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Julia L RintoulJohn C Bell
May 8, 1999·Immunology·D M HaigH R Miller
Mar 26, 2002·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·M Büttner, H J Rziha
Mar 26, 2015·Viruses·Stephen B FlemingAndrew A Mercer
Mar 12, 2008·Journal of Comparative Pathology·I E AndersonD M Haig
Sep 18, 2008·The Journal of General Virology·Gamini JayawardaneJames P Stewart
Feb 2, 2013·Veterinary Immunology and Immunopathology·Melanie R NeelandMichael J de Veer
Nov 8, 2016·Nature Communications·Jan FelixSavvas N Savvides
Feb 6, 1998·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·E M Abu Elzein, F M Housawi
Jun 8, 2007·The Journal of General Virology·Stephen B FlemingDavid M Haig

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