PMID: 6980828Jan 1, 1982Paper

Cytolytic T cells activated by H-2-controlled E molecules cross-react with A molecules

Immunogenetics
I VucakJ Klein

Abstract

Cell-mediated lymphocytotoxicity was generated in four strain combinations differing only by the cell-surface expression of the class II E molecule controlled by the H-2 complex. The four combinations were: B10.D2(R107) anti-B10.A(3R), B10.A(4R) anti-B10.A(2R), B10.GD anti-B10.D2(R101), and B10.S(7R) anti-B10.S(9R). In all four of these combinations, the stimulator expresses E molecules on the cell surface, while the responder does not. The cytolytic T lymphocytes generated in the B10.D2(R107) anti-B10.A(3R) and B10.A(4R) anti-B10.A(2R) combinations reacted not only with the stimulator but also with strains that do not express cell-surface E molecules, in particular, strains carrying the H-2f and H-2q haplotypes. The cross-reactivity with E-negative strains could be blocked by monoclonal antibodies specific for the Af or Aq molecules but not by antibodies recognizing determinants on E or class I (K) molecules. The anti-H-2f cross-reactivity could be inhibited by H-2q cold targets and, reciprocally, the anti-H-2q reactivity could be blocked by H-2f cold targets. These findings are interpreted as indicating that the cytolytic T lymphocytes stimulated by E molecules can recognize and lyse cells lacking E molecules but expressing A...Continue Reading

References

Oct 1, 1978·The Journal of Experimental Medicine·P P JonesH O McDevitt
Dec 1, 1980·European Journal of Immunology·M PierresD Caillol
Jan 1, 1981·Immunogenetics·P A Lowry, D B Murphy
Jan 1, 1982·Immunogenetics·D BirnbaumJ Colombani
Jan 1, 1981·Immunogenetics·A JuretićJ Klein

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