PMID: 2117070Sep 1, 1990Paper

Cytolytic T-lymphocyte responses to respiratory syncytial virus: effector cell phenotype and target proteins

Journal of Virology
J A NicholasP L Collins

Abstract

Cytolytic T-lymphocyte (CTL) activity specific for respiratory syncytial (RS) virus was investigated after intranasal infection of mice with RS virus, after intraperitoneal infection of mice with a recombinant vaccinia virus expressing the F glycoprotein, and after intramuscular vaccination of mice with Formalin-inactivated RS virus or a chimeric glycoprotein, FG, expressed from a recombinant baculovirus. Spleen cell cultures from mice previously infected with live RS virus or the F-protein recombinant vaccinia virus had significant CTL activity after one cycle of in vitro restimulation with RS virus, and lytic activity was derived from a major histocompatibility complex-restricted, Lyt2.2+ (CD8+) subset. CTL activity was not restimulated in spleen cells from mice that received either the Formalin-inactivated RS virus or the purified glycoprotein, FG. The protein target structures for recognition by murine CD8+ CTL were identified by using target cells infected with recombinant vaccinia viruses that individually express seven structural proteins of RS virus. Quantitation of cytolytic activity against cells expressing each target structure suggested that 22K was the major target protein for CD8+ CTL, equivalent to recognition of...Continue Reading

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Citations

Aug 1, 1995·Clinical and Experimental Immunology·A K Sharma, Z Woldehiwet
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Fernando P PolackSteven R Kleeberger
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simone VallbrachtChristine D Krempl
Dec 6, 2008·Future Virology·Elaine M Castilow, Steven M Varga
Mar 1, 1992·Journal of Medical Virology·J L KimpenP L Ogra
Feb 17, 1998·European Journal of Immunology·T HussellP J Openshaw
Jan 1, 1993·Clinical and Experimental Immunology·J L Kimpen, P L Ogra
Apr 3, 2003·The Pediatric Infectious Disease Journal·Shyam S Mohapatra
Jul 29, 2004·Viral Immunology·Ralph A Tripp
Apr 1, 2010·Future Microbiology·Robert AndersonJoanne M Langley
Feb 1, 1992·Pediatric Pulmonology·M L WittenR J Lemen
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ChangT J Braciale
Sep 28, 2006·Reviews in Medical Virology·S van Drunen Littel-van den HurkJ Kovacs-Nolan
Apr 9, 1999·Clinical Microbiology Reviews·J B Domachowske, H F Rosenberg
Feb 1, 1993·Current Problems in Pediatrics·O Ruuskanen, P L Ogra
Feb 1, 2008·The World Allergy Organization Journal·Shyam S Mohapatra, Richard F Lockey

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