PMID: 6968868Oct 2, 1980Paper

Cytolytically active murine T-cell hybrids

Nature
M NabholzJ P Johnson

Abstract

Following the demonstration that hybrids between normal B-lymphocytes and myeloma cell lines continue to secrete antibodies with the same specificity as those produced by the parental B-cells, many groups have tried to use this approach to obtain cell lines expressing T-lymphocyte functions by crossing thymoma lines not expressing any measurable activity with various types of T-cell populations. Although there have been reports that hybrids could be isolated which secrete T-cell products with immunological activity, efforts to produce functionally active hybrids from cytolytic T-cells have all been unsuccessful (refs 6, 7, and M. N. and H. D. Engers, unpublished). We have fused an established, T-cell growth factor (TCGF)-dependent murine cytolytic T-lymphocyte (CTL) line with a mouse thymoma line and have obtained hybrids with cytolytic activity when we selected the hybrids in TCGF-containing medium, while hybrids isolated in the absence of growth factor showed no detectable cytolytic potential.

References

Aug 1, 1979·European Journal of Immunology·H von BoehmerW Haas
Oct 1, 1977·European Journal of Immunology·G J Hämmerling
Aug 3, 1978·Nature·S KontiainenM Feldmann
Jan 1, 1979·The Journal of Experimental Medicine·P E BakerK A Smith
Sep 1, 1979·European Journal of Immunology·H PohlitH von Boehmer
Nov 1, 1971·Experimental Cell Research·R A BucklandA T Sumner
Jan 1, 1973·Chromosoma·M N Nesbitt, U Francke

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Citations

Dec 1, 1981·In Vitro·R H Kennett
Jul 30, 1982·Journal of Immunological Methods·W Haas, H Von Boehmer
Apr 1, 1984·Cancer Genetics and Cytogenetics·M CianfrigliaM Nabholz
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y KaufmannZ Eshhar
Jan 1, 1983·Hybridoma·B Mukherji, W Cieplinski
Aug 1, 1986·Kidney International·E G NeilsonR Mann
May 1, 1983·Experimental Cell Research·M BerebbiC Lipcey
Aug 1, 1985·European Journal of Immunology·W Haas, P Kisielow
Aug 1, 1985·European Journal of Immunology·W Haas, P Kisielow
Jan 1, 1983·Immunological Reviews·A SilvaM Nabholz
Jul 15, 1986·Cancer·A I Freeman, E Mayhew

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