Cytomegalovirus adrenalitis in acquired immunodeficiency syndrome

Endocrine Pathology
Brian ChiuZi Cheng

Abstract

Seventy-three adrenal glands of 44 patients with acquired immunodeficiency syndrome (AIDS) were examined and graded histologically to reveal cytomegaloviral (CMV) adrenalitis. The number of CMV inclusion bodies (IB) were evaluated and compared with 3 methods in 58 adrenal glands of 40 patients: histological sections, immunocytochemistry for early antigens of CMV, and in situ hybridization with biotinylated probes for CMV DNA All 73 adrenal glands contained foci of lymphocytic infiltrate. Forty (55%) showed CMV adrenalitis and necrosis, which were more extensive in the medulla than in the cortex. The number of CMV IB increased with the severity of necrosis and fibrosis (grades I, 1.0; II, 3.6; III, 27.8 IB/ thousand cells counted in 20 fields). More than 85 percent of both glands were necrotic in0 only I patient (2.3%). For the 3 methods, the means of the number of CMV IB were as follows: in situ hybridization with biotinylated probe, 17.7; immunocytochemistry, 12.9; and H&E, 8.1. However, using multivariant analysis, there was no statistically significant difference. Thirty-three (45%) adrenal glands contained no CMV IB by any of the 3 methods. We conclude that CMV adrenalitis is a common finding in patients with AIDS. Destruct...Continue Reading

References

May 1, 1990·American Journal of Clinical Pathology·U Pulakhandam, H P Dincsoy
Jan 1, 1986·The American Journal of Surgical Pathology·E R UngerD J Brigati
Nov 1, 1985·American Journal of Clinical Pathology·B J GlasgowL J Layfield
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Feb 1, 1984·Annals of Internal Medicine·M L TapperP A Seitzman
May 1, 1984·Human Pathology·D MyersonJ K McDougall
Mar 1, 1993·Endocrine Pathology·Heidrun Rotterdam, Francine Dembitzer

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Citations

Aug 14, 2002·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Evelyn R RunerJuraj Osterman

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