Abstract
CMV is associated with adverse effects in renal transplant recipients. The objective of this study was to characterize the incidence and timing of CMV and EBV infections in relation to valGCV prophylaxis in a pediatric renal transplant cohort. Retrospective cohort of pediatric renal transplant patients given universal valGCV prophylaxis and universal viral surveillance was evaluated. Demographics, prophylaxis, acute rejection, and CMV and EBV infections were abstracted. A total of 92 pediatric renal allograft recipients, 2008-2013, were included. One or more viral infections developed in 77/92 (83.7%) of the patients. EBV was the most common in 62/92 (67%) patients, irrespective of valGCV (82% of episodes occurring on valGCV). CMV DNAemia occurred in 30/92 (33%) patients, 14 episodes (47%) occurring on valGCV. Incidence of breakthrough CMV on prophylaxis was 15% and was associated with persistent DNAemia (OR 7.8, CI:1.6-32.9, P < 0.02). CMV tissue-invasive disease was not seen. CMV syndrome occurred in 10% of the cohort, only in CMV D+ patients, and only one symptomatic breakthrough infection required treatment. Out of 92, 21 (23%) had simultaneous co-infections with 2-3 viruses. Viral infections in pediatric renal transplant r...Continue Reading
References
Jan 1, 1984·Journal of Medical Virology·S C GoldsteinA S Rabson
May 10, 2002·Pediatric Transplantation·Lisa-Gaye RobinsonSteven R Nesheim
Aug 16, 2002·The New England Journal of Medicine·Hans H HirschJürg Steiger
Jul 26, 2005·Transplantation·Mieko ToyodaStanley C Jordan
Sep 17, 2005·Kidney International·Brahm VasudevEric P Cohen
Feb 16, 2007·Pediatric Transplantation·Li LiMinnie M Sarwal
Mar 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W VaudryUNKNOWN Valcyte WV16726 Study Group
Oct 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·George J Schwartz, Dana F Work
Oct 22, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R B Freeman
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Mar 13, 2010·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Jul 10, 2010·Journal of the American Society of Nephrology : JASN·Jodi M SmithRuth A McDonald
Nov 16, 2010·Transplantation·Andres F Camacho-GonzalezJoseph A Hilinski
Jan 5, 2011·Pediatric Transplantation·Judith M Martin, Lara A Danziger-Isakov
Jun 10, 2011·Journal of Clinical Microbiology·Zdenek NovakSuresh B Boppana
Oct 18, 2011·Transplantation·Peter A AndrewsChas Newstead
Apr 27, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Britta HöckerBurkhard Tönshoff
Jun 15, 2012·Pediatric Transplantation·Brian RhaMasako Shimamura
Nov 24, 2012·Transplant Infectious Disease : an Official Journal of the Transplantation Society·R HellemansJ L Bosmans
May 4, 2013·Transplantation·Amelia K Le PageWilliam D Rawlinson
Jul 31, 2013·Pediatric Transplantation·Hidde JongsmaKarlien Cransberg
Jul 31, 2013·Transplantation·Camille N KottonUNKNOWN Transplantation Society International CMV Consensus Group
Mar 8, 2014·Transplantation Reviews·Antonio RomanUNKNOWN ATOS working group
Jan 1, 2014·The Open Urology & Nephrology Journal·Faris HashimVikas R Dharnidharka
Nov 1, 2015·Transplantation Proceedings·D PaiR A Mann
Nov 19, 2015·Pediatric Transplantation·Cameron L JordanKatherine Twombley
Jan 7, 2016·Transplantation·Britta HöckerBurkhard Tönshoff
Oct 6, 2016·Pediatric Transplantation·Bernadette M CameronFiona E Mackie
Mar 30, 2018·Transplantation·Camille N KottonUNKNOWN The Transplantation Society International CMV Consensus Group
Citations
Aug 5, 2019·Pediatric Research·Sawsan AlbatatiTom D Blydt-Hansen
Aug 30, 2019·Journal of Medical Virology·Flavia Savassi-RibasRafael Brandão Varella
Dec 17, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Scott PangonisLara Danziger-Isakov
Dec 2, 2020·Transplantation Proceedings·Loes OomenCharlotte M H H T Bootsma-Robroeks
Apr 8, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·James McCaffreyMohan Shenoy
Sep 2, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kristen G Valencia DerayClaire E Bocchini
Jan 8, 2022·Pediatric Transplantation·Kevin J DownesYun Li