Cytomegalovirus and immunotherapy: opportunistic pathogen, novel target for cancer and a promising vaccine vector

Immunotherapy
Michael QuinnChristopher M Snyder

Abstract

Cytomegalovirus (CMV) is a β-herpesvirus that infects most people in the world and is almost always asymptomatic in the healthy host. However, CMV persists for life, requiring continuous immune surveillance to prevent disease and thus, CMV is a frequent complication in immune compromised patients. Many groups have been exploring the potential for adoptive T-cell therapies to control CMV reactivation as well as the progression of solid tumors harboring CMV. In addition, CMV itself is being explored as a vaccine vector for eliciting potent T-cell responses. This review will discuss key features of the basic biology of CMV-specific T cells as well as highlighting unanswered questions and ongoing work in the development of T-cell-based immunotherapies to target CMV.

References

Apr 1, 1992·Journal of Virology·P LucinU H Koszinowski
Apr 1, 1989·The Journal of Experimental Medicine·S JonjićU H Koszinowski
Mar 31, 1995·Journal of Molecular Biology·D J McGeochE A Telford
Dec 6, 1994·Proceedings of the National Academy of Sciences of the United States of America·K KondoE S Mocarski
Apr 1, 1993·The Journal of Infectious Diseases·S C Henry, J D Hamilton
Jan 6, 1997·Virology·J L PollockH W Virgin
Jan 7, 1998·Journal of Virology·A J KoffronM I Abecassis
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·G HahnE S Mocarski
Dec 16, 1998·Journal of Virology·S K KurzM J Reddehase
Apr 3, 2002·Nature Medicine·Victor AppaySarah L Rowland-Jones
Aug 6, 2002·Current Opinion in Microbiology·Michael A Jarvis, Jay A Nelson
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Urs KarrerPaul Klenerman
Sep 17, 2003·Clinical and Experimental Immunology·H KomatsuP Klenerman
Jun 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·M G SMITH
Nov 19, 2003·Microbes and Infection·Astrid KrmpoticStipan Jonjic
Jan 30, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Olle RingdénMats Remberger
Feb 14, 2004·Journal of Virology·Urs KarrerPaul Klenerman
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laila E GamadiaRené A W Van Lier
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ester M M van LeeuwenIneke J M ten Berge
Sep 9, 2005·The Journal of Experimental Medicine·Andrew W SylwesterLouis J Picker
Aug 25, 2006·Journal of Virology·Christian O SimonNatascha K A Grzimek
Dec 13, 2006·The Journal of Experimental Medicine·Joseph P CasazzaRichard A Koup
Dec 7, 2007·The Journal of Clinical Investigation·Carolina BergerStanley R Riddell
Mar 18, 2008·Medical Microbiology and Immunology·Rafaela HoltappelsMatthias J Reddehase
Jul 22, 2008·Current Topics in Microbiology and Immunology·M J ReddehaseN K A Grzimek

❮ Previous
Next ❯

Citations

Sep 30, 2017·European Journal of Immunology·Martin R GoodierVanda Juranić Lisnić
Feb 17, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dan A ErkesChristopher M Snyder
Sep 13, 2019·International Journal of Molecular Sciences·Jian LiuHua Zhu
Jul 5, 2018·Journal of Translational Medicine·Zhenjiang LiuMarkus Maeurer
Apr 12, 2019·Medical Microbiology and Immunology·Luka Cicin-Sain
Mar 7, 2020·Molecular Therapy Oncolytics·Layal MassaraMyriam Capone
Apr 6, 2021·Frontiers in Cellular and Infection Microbiology·Kumari Asha, Neelam Sharma-Walia
Jul 17, 2021·Nature Immunology·Katharine E Block, Stephen C Jameson
Aug 13, 2021·PloS One·DeVon Hunter-SchlichtingHeather H Nelson

❮ Previous
Next ❯

Methods Mentioned

BETA
contraception

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.