Cytomegalovirus antigenemia in acquired immunodeficiency syndrome patients with untreated cytomegalovirus retinitis

American Journal of Ophthalmology
C S PannutiR Belfort Júnior

Abstract

To determine the frequency of cytomegalovirus (CMV) viremia in patients with acquired immunodeficiency syndrome (AIDS) and untreated CMV retinitis using conventional cell culture isolation and the sensitive CMV antigenemia assay. We examined 24 AIDS patients with ophthalmologic diagnosis of untreated CMV retinitis and 24 AIDS patients without present or past retinitis (control patients) from three medical centers between September 1992 and March 1994. Cytomegalovirus antigenemia was detected by an indirect peroxidase staining in 300,000 cytocentrifuged neutrophils, using a mixture of murine monoclonal antibodies directed against the pp65 lower matrix protein of CMV. Positive antigenemia was demonstrated in eight (33.3%) of the 24 retinitis patients and in none of the 24 control patients (P < .001). Only two of the eight antigenemia-positive patients had a concurrent positive CMV isolation from blood leukocytes by conventional cell culture assay. These results emphasize the risk of extraocular disease in AIDS patients with CMV retinitis because the virus is often present in peripheral blood leukocytes. The CMV antigenemia assay may be a simple and rapid means of identifying those patients with unilateral retinitis at highest ris...Continue Reading

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Citations

Jan 26, 2005·The Journal of Infection·Sandra H A BononSandra C B Costa
Jul 6, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C Muccioli, R Belfort
Nov 7, 2006·Revista Do Instituto De Medicina Tropical De São Paulo·Sandra Helena Alves BononSandra Cecília Botelho Costa
Sep 8, 2007·Revista Do Instituto De Medicina Tropical De São Paulo·Luis Fernando WaibSandra Cecília Botelho Costa
Sep 1, 2000·Revista Do Instituto De Medicina Tropical De São Paulo·C L do CantoC S Pannuti
Jan 10, 2002·Bone Marrow Transplantation·C M MachadoC S Pannuti
Sep 23, 2000·Journal of Clinical Microbiology·S M Lipson, P Della-Latta
Feb 3, 2000·Journal of Clinical Microbiology·P WattanamanoM A Beilke

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