Cytomegalovirus disease in hematopoietic stem cell transplant patients: current and future therapeutic options

Current Opinion in Infectious Diseases
Shigeo FujiMarkus Kapp

Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become one of the standard treatment for hematological diseases. Although the clinical outcome has improved significantly during the last decades, the morbidity and mortality after allo-HSCT are still obstacles to cure. Out of major morbidities, opportunistic virus infections such as cytomegalovirus (CMV) infection are important complications, in particular in patients who received human leukocyte antigen-mismatched HSCT. Here, we aim to summarize information about current and future therapeutic options in CMV disease after allo-HSCT. Recently, not only new drugs but also adoptive T-cell therapy are tested in the setting of clinical trials. CMV prophylaxis using letermovir significantly reduced the incidence of CMV disease in comparison to placebo in a phase III clinical trial. Meanwhile, adoptive T-cell therapies which are fully adapted to good manufacturing practice (GMP) conditions are now available. A recent multicenter study in Germany showed a promising result using Streptamer-isolated T-cell therapy. With the recent development of CMV-targeted therapy, treatment strategies of CMV infection would be further sophisticated in the near future. VIDEO ABSTRACT:...Continue Reading

References

May 29, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Kenneth MicklethwaiteDavid Gottlieb
Aug 12, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Margaret PollackMichael Boeckh
Dec 15, 2010·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karl S PeggsMark W Lowdell
May 19, 2011·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S BorchersE Mischak-Weissinger
Sep 20, 2011·Best Practice & Research. Clinical Haematology·Shigeo FujiHermann Einsele
Mar 9, 2012·Clinical and Vaccine Immunology : CVI·Pablo J E J van de BergIneke J M ten Berge
Jun 12, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Margaret L GreenMichael Boeckh
Sep 27, 2013·The New England Journal of Medicine·Francisco M MartyUNKNOWN CMX001-201 Clinical Study Group
Dec 18, 2013·Diagnostic Microbiology and Infectious Disease·Sylvia BorchersEva M Weissinger
Mar 18, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Veronique ErardMichael Boeckh
Feb 27, 2016·Cytometry. Part B, Clinical Cytometry·Miriam CiáurrizNatalia Ramírez
Apr 5, 2016·Bone Marrow Transplantation·M RamanathanM L Riches
Apr 5, 2016·Bone Marrow Transplantation·R J O'ReillyE Doubrovina
Apr 20, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·R Grant RoweLeslie Lehmann
Jun 28, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Ugur SahinTaner Demirer
Dec 17, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jiwon JungSung-Han Kim

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Citations

Dec 6, 2017·The Journal of General Virology·Sebastian NeuberEva Maria Borst
Jun 1, 2018·PLoS Pathogens·Valentina VoigtMariapia A Degli-Esposti
Apr 14, 2018·European Journal of Haematology·Thomas WidmannMartina Sester
Nov 28, 2018·Expert Opinion on Drug Metabolism & Toxicology·Barbara DeleenheerJohan Maertens
Oct 28, 2018·Bioscience Reports·Kyoung Hwa LeeSang Hoon Han
Jun 4, 2019·International Journal of Molecular Sciences·Sung-Yeon ChoHee-Je Kim
Aug 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Roy F ChemalyUNKNOWN Resistant Definitions Working Group of the Cytomegalovirus Drug Development Forum
Aug 15, 2021·Antiviral Research·Joseph A CombsKevin J Zwezdaryk

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