Cytomegalovirus establishes a latent reservoir and triggers long-lasting inflammation in the eye

PLoS Pathogens
Valentina VoigtMariapia A Degli-Esposti

Abstract

Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like the eye, including the neural retina, which have been considered immune privileged. Whether this is a peculiarity of exotic viruses remains unclear, since the impact of more common viral infections on neural compartments has not been examined, especially in immunocompetent hosts. Cytomegalovirus is a common, universally distributed pathogen, generally innocuous in healthy individuals. Whether in immunocompetent hosts cytomegalovirus can access the eye, and reside there indefinitely, was unknown. Using the well-established murine cytomegalovirus infection model, we show that systemic infection of immunocompetent hosts results in broad ocular infection, chronic inflammation and establishment of a latent viral pool in the eye. Infection leads to infiltration and accumulation of anti-viral CD8+ T cells in the eye, and to the development of tissue resident memory T cells that localize to the eye, including the retina. These findings identify the eye as an unexpected reservoir for cytomegalovirus, and suggest that common viruses may target this organ more frequently than appreciated. Notably, they also highli...Continue Reading

References

Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M A JacobsonE T Cunningham
Oct 4, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Matthias J ReddehaseNatascha K A Grzimek
Jan 15, 2004·Journal of Virology·Jon D ReuterAnthony N Van Den Pol
Feb 24, 2006·American Journal of Ophthalmology·Noriko KoizumiShigeru Kinoshita
Jan 9, 2007·Ophthalmology·Soon-Phaik CheeBan Hock Tan
Feb 14, 2007·Ophthalmology·Lonneke A A van BoxtelLeonoor I Los
Aug 3, 2007·Ophthalmology·Noriko KoizumiShigeru Kinoshita
Jan 4, 2008·Investigative Ophthalmology & Visual Science·Ming ZhangSally S Atherton
Feb 8, 2008·American Journal of Ophthalmology·Soon-Phaik CheeBan Hock Tan
Feb 13, 2008·The Journal of Experimental Medicine·Thad KoontzWilliam J Britt
Mar 29, 2008·Virology Journal·Petros I RafailidisMatthew E Falagas
May 10, 2008·Eye·A GuptaD G Pandian
Jul 24, 2008·JAMA : the Journal of the American Medical Association·Ajit P LimayeMichael Boeckh
Jan 13, 2009·Clinical Microbiology Reviews·Tania Crough, Rajiv Khanna
Jan 13, 2009·Clinical Microbiology Reviews·Maxim C-J CheeranMark R Schleiss
Jun 19, 2009·Journal of Virology·Christof K SeckertNatascha K A Grzimek
Mar 3, 2010·Immunological Reviews·John V ForresterPaul G McMenamin
Jun 2, 2010·The Journal of Experimental Medicine·Daniel M AndrewsMariapia A Degli-Esposti
Jun 22, 2010·Reviews in Medical Virology·Michael J CannonTerri B Hyde
Dec 17, 2011·Eye·A Carmichael
Aug 14, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L GabrielliT Lazzarotto
Jan 15, 2013·The American Journal of Pathology·Martin S ZinkernagelMariapia A Degli-Esposti
May 16, 2013·Blood·Monique L OngMariapia A Degli-Esposti
May 25, 2013·Nature Reviews. Immunology·Jayakrishna AmbatiBradley D Gelfand
Aug 2, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Tiziana LazzarottoMaria Paola Landini
Sep 11, 2014·The Journal of Pathology·Paul GriffithsMatt Reeves
Apr 22, 2015·Medical Microbiology and Immunology·J G Patrick Sissons, Mark R Wills
May 8, 2015·The New England Journal of Medicine·Jay B VarkeySteven Yeh
Nov 4, 2015·Cell Reports·Corinne J SmithChristopher M Snyder
Nov 13, 2015·The New England Journal of Medicine·Steven YehIan Crozier
Mar 24, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Amanda TiffanyIza Ciglenecki
Apr 26, 2016·Nature Reviews. Immunology·Paul Klenerman, Annette Oxenius
Sep 11, 2016·Cell Reports·Jonathan J MinerRajendra S Apte
Dec 18, 2016·Current Opinion in Virology·Pamela C RosatoDavid Masopust
Mar 30, 2017·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Alexander D PortMrinali P Gupta
May 16, 2017·Current Opinion in Infectious Diseases·Shigeo FujiMarkus Kapp

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Citations

Nov 28, 2019·The Journal of General Virology·Aidan J NorburyJillian M Carr
Oct 13, 2018·Nature Reviews. Neuroscience·John V ForresterSamantha J Dando
Oct 4, 2018·Current Opinion in Ophthalmology·Ashlin Joye, John A Gonzales
Oct 3, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Haihan JiaoHolly R Chinnery
Feb 15, 2019·Frontiers in Immunology·Mathew Clement, Ian R Humphreys
Sep 4, 2020·Translational Vision Science & Technology·Alicia A BrunetLivia S Carvalho
Jan 10, 2021·Journal of Medical Virology·Xinyan ZhangFeng Fang
Jan 1, 2021·International Journal of Molecular Sciences·Michelle A Fisher, Megan L Lloyd
Feb 4, 2021·Cell Biology International·Scheilla T StrumilloMarli F Curcio
Aug 13, 2021·PloS One·DeVon Hunter-SchlichtingHeather H Nelson

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Methods Mentioned

BETA
flow cytometry
FACS
dissection
PCR
FCS

Software Mentioned

Bioptigen OCT
InStat
FlowJo
GraphPad

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