Cytomegalovirus infection accelerates obliterative bronchiolitis of rat tracheal allografts

Transplant International : Official Journal of the European Society for Organ Transplantation
K B LemströmP K Koskinen

Abstract

A cascade of inflammation and injury of the airway wall followed by a fibroproliferative process that results in airway obstruction has been suggested as the explanation of the process of obliterative bronchiolitis (OB) in lung allograft recipients. To determine the impact of rat cytomegalovirus (RCMV) infection on the development of OB, heterotopic rat tracheal allografts were transplanted from DA donors to WF recipients immunosuppressed with 2 mg/kg per day cyclosporine A. Chronic RCMV infection was similarly established 8 weeks before transplantation in donors alone (D+/R-), recipients alone (D-/R+), and both donors and recipients (D+/R+). The control rats were left non-infected, but were similarly immunosuppressed. The results of this study demonstrate that both acute and chronic recipient RCMV infection, but not donor infection, amplify the development of experimental OB in the rat and suggest that RCMV infection-associated immune response, rather than the viral load in the graft, is essential for the development of the accelerated form of OB.

References


❮ Previous
Next ❯

Citations

Jul 29, 1999·American Journal of Respiratory Cell and Molecular Biology·G W HunninghakeL J Geist

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Respiratory and Critical Care Medicine
P K KoskinenK B Lemström
The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
B HausenR E Morris
© 2021 Meta ULC. All rights reserved