Abstract
Human cytomegalovirus (HCMV) infection is an important risk factor for atherosclerosis (AS). Numerous studies have been conducted to analyze the association between HCMV infection and risk of AS, but no clear consensus has been reached. So the objective of this paper was aimed to demonstrate the relationship between HCMV and AS by doing a meta-analysis. Relative literature was searched through the electronic databases PubMed, Embase, and CNKI. Data were accurately assessed and analyzed independently by two investigators. Ultimately, the 30 studies, involving 3328 cases and 2090 controls were included in our meta-analysis. The positive ratio of HCMV IgG, IgM, DNA and pp65 were, respectively, 63.26% (923/1459), 25.46% (69/271), 33.69% (381/1131), and 50.32% (158/314) in case patients. Meanwhile the positive ratio of HCMV IgG, IgM, DNA, and pp65 were, respectively, 52.12% (541/1038), 1.55% (3/194), 13.72% (79/576), and 12.26% (28/229) in control subjects. The positive ratio of HCMV infection was higher in atherosclerosis group than that in non-atherosclerosis group. Especially in Asian group, calculated odds ratios for the presence of HCMV infection in IgG-based HCMV tests, IgM-based tests, PCR-based tests, and pp65-based tests, e...Continue Reading
References
Aug 8, 1987·Lancet·E AdamM E DeBakey
Feb 1, 1994·Journal of Medical Virology·J L MelnickM E DeBakey
Jan 1, 1994·Journal of Medical Virology·P D SorlieJ L Melnick
Sep 1, 1996·Circulation·F J NietoM Szklo
Apr 1, 1997·Diabetes Research and Clinical Practice·F L VisserenR J Diepersloot
Oct 23, 1997·Circulation·B ChiuI W Fong
Feb 5, 1999·Reviews of Physiology, Biochemistry and Pharmacology·D M JuilfsJ A Beavo
Jul 27, 2001·Atherosclerosis·M C BorgiaM R Capobianchi
Apr 10, 2002·Pathology International·Yu Shi, Osamu Tokunaga
Mar 28, 2003·American Heart Journal·Daisy G M BloemenkampYolanda van der Graaf
Jun 5, 2003·Journal of Clinical Pathology·T-M LinH-L Eng
Dec 4, 2003·Clinical and Experimental Medicine·A BlumM Weinberg
Dec 2, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ali I IbrahimBarbara C Gärtner
Feb 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Elisabet Vila, Mercedes Salaices
May 16, 2006·Acta Microbiologica Et Immunologica Hungarica·D VirokValeria Endresz
May 2, 2008·Journal of Virology·Jerome DumortierJay A Nelson
Jun 6, 2009·American Journal of Hypertension·Sante D PierdomenicoFranco Cuccurullo
May 3, 2011·Journal of Korean Medical Science·Hack-Lyoung KimKyueng-Whan Min
Aug 19, 2011·Journal of Clinical Immunology·Chiara FornaraGiuseppe Gerna
Oct 21, 2011·Thrombosis and Haemostasis·M E Rosenfeld, L A Campbell
Nov 26, 2011·BMC Infectious Diseases·Ying ShiZhiyong Zhang
Feb 9, 2012·Molecular Biology Reports·Ya-Nan JiXiao-Hu Chen
Jun 8, 2012·CNS Neuroscience & Therapeutics·Zheng-Rong HuangJun Cai
Nov 23, 2013·BMC Neurology·Juan ChenZhongwen Sun
Mar 20, 2014·BMC Medicine·Eiji MatsuuraMichael T Nurmohamed
Dec 3, 2014·Journal of Critical Care·Frantzeska G FrantzeskakiIoanna Dimopoulou
Dec 30, 2014·Atherosclerosis·Gareth W JonesBrendan J Jenkins
Apr 4, 2015·Jundishapur Journal of Microbiology·Habib HeybarMahmood Latifi
Dec 29, 2015·The Journal of Pediatrics·Michelle A E JansenHenriette A Moll
Dec 31, 2015·Open Forum Infectious Diseases·Paul M LantosGeeta K Swamy
Dec 31, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Jun ZhangXiao-jing Jiang
Mar 17, 2016·Wiener klinische Wochenschrift·Jing HuiFang He
Nov 5, 2016·Virus Research·Ya-Li LvLi-Hong Liu
Citations
Oct 13, 2017·Reviews in Medical Virology·Aline Semblano Carreira FalcãoJuarez Antonio Simões Quaresma
Apr 8, 2020·Acta Biochimica Et Biophysica Sinica·Wenbo Zhu, Shuangquan Liu
May 30, 2020·The Journal of Gene Medicine·Dan LiJiawei Wang
Mar 27, 2019·International Journal of Molecular Sciences·Donald J Alcendor
Apr 24, 2020·Frontiers in Immunology·Riccardo NegriniAntonella Savio
Feb 18, 2021·Analytical Chemistry·Weiying ZhangJoseph B Margolick