Cytomegalovirus infection does not increase the risk of vanishing bile duct syndrome after liver transplantation

Transplant International : Official Journal of the European Society for Organ Transplantation
A P van den BergM J Slooff

Abstract

Cytomegalovirus (CMV) infection and HLA-DR sharing have been reported to be associated with the development of vanishing bile duct syndrome (VBDS) after liver transplantation. We retrospectively analyzed the importance of these risk factors for VBDS in 126 consecutive recipients of a first transplant. In contrast to previous studies, CMV was monitored strictly using the antigenemia assay, a quantitative marker of the viral load. Patient and graft survival were comparable in patients with and without CMV infection. The incidence of VBDS was low, regardless of the CMV infection status or degree of HLA-DR sharing. Improvements in the early diagnosis and treatment of CMV infection may have eliminated its negative influence on graft survival.

Citations

Jan 15, 2003·Gastroenterología y hepatología·J L Pérez CalleG Clemente
Nov 30, 2004·The Lancet Infectious Diseases·Maher K Gandhi, Rajiv Khanna
Jun 22, 2002·The Journal of Infection·J G P Sissons, A J Carmichael
May 3, 2016·Transplantation Reviews·J Torre-CisnerosUNKNOWN Spanish Network for Research in Infectious Diseases (REIPI)
Mar 21, 2009·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·F HansesC E Wrede
Jun 29, 2004·World Journal of Gastroenterology : WJG·Liang-Hui Gao, Shu-Sen Zheng
Oct 29, 2008·Neuropsychology Review·Lauren KenworthyGregory L Wallace
Aug 12, 2009·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Rie ItoHiroyuki Nakazawa

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