PMID: 9638878Jun 25, 1998Paper

Cytomegalovirus infection in kidney transplant patients: clinical manifestations and diagnosis

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
W SułowiczI Zgórniak-Nowosielska

Abstract

Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality after solid organ transplantation. CMV infection after kidney transplantation was confirmed in 19 (54.3%) out of 35 patients. 16 of these (84.2%) developed CMV disease. CMV infection was diagnosed based on a fourfold or greater increase of anti-CMV IgG antibody titre, detection of CMV-IgM antibodies and/or virus isolation. Primary infection was observed in 3 patients, reactivation in 9 and an undefined type of infection in 7. In most patients (63%), infection was diagnosed in the first 2 months, and in 3 patients, after 3, 5 and 9 years following kidney transplantation. The most frequent symptoms of CMV disease were fever (58%), pneumonitis (26.3%) and enterocolitis (15.8%). In 53% of the patients, CMV infection co-occurred with other pathogens such as Candida albicans. Cryptococcus neoformans, bacteria or viruses (HBV, HCV, HSV). Treatment with polyvalent globulin (Sandoglobin) or hyperimmune globulin (Cytotect), in combination with ganciclovir in 7 patients, resulted in a regression of CMV disease.

References

Jan 1, 1995·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C G Newstead
Jan 1, 1994·Scandinavian Journal of Infectious Diseases·A BoehlerG Keusch
May 15, 1996·Transplantation·R PatelC V Paya
Jan 1, 1997·Immunological Investigations·B M Murray

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