Cytomegalovirus infection in patients with lymphoma: an important cause of morbidity and mortality

Clinical Lymphoma & Myeloma
Harrys A TorresRoy F Chemaly

Abstract

Cytomegalovirus (CMV) antigenemia (CMV-A) and CMV disease (CMV-D), known causes of morbidity and mortality among patients with leukemia and recipients of hematopoietic stem cell transplantations, are described sporadically in patients with lymphoma. We sought to determine the risk factors and outcome of CMV-A and CMV-D among patients with lymphoma. We conducted a retrospective cohort study with such patients identified between 1997 and 2003 at The University of Texas M. D. Anderson Cancer Center. Seventy-one patients with 82 episodes of CMV-A and/or CMV-D (CMV-A in 38 episodes and CMV-D in 44 episodes) were studied. Cytomegalovirus antigenemia and/or CMV-D were more common among patients with non-Hodgkin's lymphoma than among those with Hodgkin's disease (P = 0.01). Most CMV infectious episodes occurred in patients who had active (88%) and stage III/IV lymphoma (84%). Eleven of 65 patients (17%) with outcome data died with CMV-A and/or CMV-D. Death with CMV infection was more common among patients with CMV-D than among those with CMV-A (29% vs. 3%, respectively, P = 0.005). Predictors of death by univariate analysis included intensive care unit admission, mechanical ventilation, high antigenemia burden, relapse of CMV-A and/or ...Continue Reading

References

Jul 1, 1988·Reviews of Infectious Diseases·C CrumpackerP Watkins
Mar 1, 1966·Annals of Internal Medicine·C P DuvallW P Rowe
Aug 29, 1966·JAMA : the Journal of the American Medical Association·A R CasazzaP P Carbone
Jun 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J R MeraJ M Goodrich
Apr 8, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Q NguyenE Whimbey
Feb 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Q NguyenE Whimbey
Jul 31, 2001·Bone Marrow Transplantation·S KonoplevE Whimbey
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanCarlos Paya
Oct 4, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Rafael E de la HozChristopher Sherlock
Aug 9, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A EriceUNKNOWN AIDS Clinical Trials Group Protocol 360 Study Team
Aug 12, 2003·Cancer·Alessandra FerrajoliMichael J Keating
Sep 27, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Annunziata MannaPaolo Pronzato
Aug 4, 2005·Cancer·Roy F ChemalyIssam I Raad

❮ Previous
Next ❯

Citations

May 2, 2013·Leukemia & Lymphoma·Matthew Rong Jie TayThuan Tong Tan
Jan 11, 2014·Expert Review of Anti-infective Therapy·Cecilia Söderberg-Nauclér
May 24, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yung-Chih WangFeng-Yee Chang
Nov 3, 2015·Journal of Pediatric Hematology/oncology·Mi Seon HanEun Hwa Choi
Aug 12, 2014·Annals of Hematology·Tetsuo HasegawaTomonori Nakazato
Dec 3, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·H A TorresR F Chemaly
Sep 15, 2010·Journal of Intensive Care Medicine·Karen Joan VigilRoy F Chemaly
Apr 30, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Risa FullerSamantha E Jacobs
Jul 15, 2011·Administration and Policy in Mental Health·Sungkyu Lee, Jason Matejkowski
Jul 6, 2014·Academic Psychiatry : the Journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·Mary K SmithYixing Chen
Aug 23, 2018·Journal of General Internal Medicine·Kathleen CrapanzanoWin May
Dec 5, 2017·Journal of Pediatric Hematology/oncology·Anirban DasArpita Bhattacharyya
Dec 4, 2019·Pediatric Blood & Cancer·Mi Seon HanHee Young Shin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.